959795-77-8

Basic information

• Product Name: 1-[4-(6-Aminopyridin-3-Yl)Piperazin-1-yl]Ethan-1-One
• Synonyms: 1-[4-(6-Amino-3-pyridinyl)-1-piperazinyl]ethanone
• CAS NO: 959795-77-8
• Molecular Formula: C₁₁H₁₆N₄O
• Molecular Weight: 220.270905
• Mol File: 959795-77-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-[4-(6-Aminopyridin-3-Yl)Piperazin-1-yl]Ethan-1-One(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(6-Aminopyridin-3-Yl)Piperazin-1-yl]Ethan-1-One(959795-77-8)
• EPA Substance Registry System: 1-[4-(6-Aminopyridin-3-Yl)Piperazin-1-yl]Ethan-1-One(959795-77-8)

Safety Data

• Hazardous Substances Data: 959795-77-8(Hazardous Substances Data)

Usage

Synonyms

Lu AF60097

Molecular Function

Selective and potent antagonist of the histamine H3 receptor

Receptor Interaction

Blocks the histamine H3 receptor, regulating the release of neurotransmitters in the brain

Therapeutic Potential

Treatment of various neurological and psychiatric disorders

Research Status

Ongoing research to understand its pharmacological properties and potential therapeutic uses

Chemical Structure

A small molecule with a piperazine ring connected to an ethanone group, featuring a 6-aminopyridin-3-yl group attached to the piperazine ring

Molecular Target

Histamine H3 receptor

Mechanism of Action

Inhibition of histamine H3 receptor activity, potentially leading to increased neurotransmitter release and improved neuronal communication

Current Applications

Preclinical and experimental research for potential therapeutic uses in neurological and psychiatric disorders

Upstream product

• 13889-98-0 N-acetylpiperidine 
• 39856-50-3 5-bromo2-nitropyridine 
• 852225-20-8 1-(4-(6-nitropyridin-3-yl)piperazin-1-yl)ethan-1-one 

Downstream Products

• 1243245-98-8 N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(4-iodophenyl)acetamide 
• 1243245-97-7 N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(4-chloro-3-fluorophenyl)acetamide 
• 1243244-37-2 N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-cyano-4-(2-methylpyridin-4-yl)phenyl)acetamide 
• 1243245-07-9 N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-methoxy-4-(2-methylpyridin-4-yl)phenyl)acetamide 
• 1243245-16-0 N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(2-fluoro-5-methyl-4-(2-methylpyridin-4-yl)phenyl)acetamide 
• 1243245-96-6 N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(4-bromo-3-methylphenyl)acetamide 
• 1243245-18-2 N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(2’-fluoro-3-methyl-2,4’-bipyridin-5-yl)acetamide 
• 1243245-26-2 N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(4-(2-(difluoromethyl)pyridin-4-yl)phenyl)acetamide 
• 1243245-35-3 N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-cyano-4-(2-fluoropyridin-4-yl)phenyl)acetamide 
• 1243249-25-3 N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(3-fluoro-4-(2-fluoropyridin-4-yl)phenyl)acetamide 
• 1243246-41-4 4-(2-(5-(4-acetylpiperazin-1-yl)pyridin-2-ylamino)-2-oxoethyl)-2-chlorophenyl trifluoromethanesulfonate 
• 1243246-15-2 N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(4-bromo-3-(trifluoromethyl)phenyl)acetamide 

Relevant articles and documents

DERIVATIVES OF 4-(IMIDAZO[L,2-A]PYRIDIN-3-YL)-N-(PYRIDINYL)PYRIMIDIN- 2-AMINE AS THERAPEUTIC AGENTS

A novel class of heteroaryl compounds for use in the prevention and/or treatment of proliferative diseases and conditions including cancers. The compounds are considered to be capable of inhibiting cell proliferation by inhibiting the activity of FLT3 and its mutant forms and/or other protein kinases such as CDKs. The compounds have the general structure I:

Pyrimidine and pyrimidine dione CDK4/6 kinase inhibitors and uses thereof

The invention belongs to the field of chemical medicine, relates to pyrimidine and pyrimidine dione CDK4/6 kinase inhibitor and its application, the pyrimidine and pyrimidine dione CDK4/6 kinase inhibitors of formula I shown in the compound or its pharmaceutically acceptable salt, and pharmaceutical compositions containing these compounds and these compounds or compositions of the pharmaceutical preparation in the application, the present invention provides a pyrimidine and pyrimidine dione compounds to CDK4 and CDK6 kinase has better inhibition activity, to breast cancer cell has significant inhibition function, can effectively reduce the incidence of tumor, extension of the tumor to the lives of patients,

Highly Potent, Selective, and Orally Bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine Cyclin-Dependent Kinases 4 and 6 Inhibitors as Anticancer Drug Candidates: Design, Synthesis, and Evaluation

Cyclin D dependent kinases (CDK4 and CDK6) regulate entry into S phase of the cell cycle and are validated targets for anticancer drug discovery. Herein we detail the discovery of a novel series of 4-thiazol-N-(pyridin-2-yl)pyrimidin-2-amine derivatives as highly potent and selective inhibitors of CDK4 and CDK6. Medicinal chemistry optimization resulted in 83, an orally bioavailable inhibitor molecule with remarkable selectivity. Repeated oral administration of 83 caused marked inhibition of tumor growth in MV4-11 acute myeloid leukemia mouse xenografts without having a negative effect on body weight and showing any sign of clinical toxicity. The data merit 83 as a clinical development candidate.