95980-02-2

Basic information

• Product Name: 7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIMIDIN-5-OL
• Synonyms: 7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIMIDIN-5-OL
• CAS NO: 95980-02-2
• Molecular Formula: C₁₃H₁₁N₃O
• Molecular Weight: 225.25
• Mol File: 95980-02-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 315-317°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.3g/cm³
• Refractive Index: 1.682
• CAS DataBase Reference: 7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIMIDIN-5-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIMIDIN-5-OL(95980-02-2)
• EPA Substance Registry System: 7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIMIDIN-5-OL(95980-02-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 95980-02-2(Hazardous Substances Data)

Usage

General Description

7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIMIDIN-5-OL is a chemical compound with the molecular formula C13H10N4O. It is a heterocyclic compound that contains an imidazo[1,2-a]pyrimidine ring system with a methyl and phenyl group attached to it. 7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIMIDIN-5-OL has been studied for its potential pharmacological properties, including its ability to inhibit specific enzymatic pathways. It is also of interest in the field of medicinal chemistry for its potential as a drug candidate for various therapeutic applications. The compound's structure and properties make it a subject of research for its potential biological activities and as a starting point for the synthesis of new chemical entities.

InChI:InChI=1/C13H11N3O/c1-9-7-12(17)16-8-11(15-13(16)14-9)10-5-3-2-4-6-10/h2-8,17H,1H3

Upstream product

• 70-11-1 α-bromoacetophenone 
• 3977-29-5 2-amino-6-methylpyrimidin-4-ol 

Downstream Products

• 13994-88-2 5-methoxy-7-methyl-2-phenylimidazo[1,2-a]pyrimidine 
• 108203-46-9 5-chloro-7-methyl-2-phenylimidazo[1,2-a]pyrimidine 

Relevant articles and documents

Identification of Potent in Vivo Autotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain

Autotaxin (ATX, also known as ENPP2) is a predominant lysophosphatidic acid (LPA)-producing enzyme in the body, and LPA regulates various physiological functions, such as angiogenesis and wound healing, as well as pathological functions, including proliferation, metastasis, and fibrosis, via specific LPA receptors. Therefore, the ATX-LPA axis is a promising therapeutic target for dozens of diseases, including cancers, pulmonary and liver fibroses, and neuropathic pain. Previous structural studies revealed that the catalytic domain of ATX has a hydrophobic pocket and a hydrophobic channel; these serve to recognize the substrate, lysophosphatidylcholine (LPC), and deliver generated LPA to LPA receptors on the plasma membrane. Most reported ATX inhibitors bind to either the hydrophobic pocket or the hydrophobic channel. Herein, we present a unique ATX inhibitor that binds mainly to the hydrophobic pocket and also partly to the hydrophobic channel, inhibiting ATX activity with high potency and selectivity in vitro and in vivo. Notably, our inhibitor can rescue the cardia bifida (two hearts) phenotype in ATX-overexpressing zebrafish embryos.