959841-63-5

Upstream product

• 959841-61-3 5-[(6-chloro-4,5-dimethylpyridazin-3-yl)(cyano)methyl]-2-fluorobenzonitrile 
• 959841-62-4 5-[(6-Chloro-4,5-dimethylpyridazin-3-yl)methyl]-2-fluorobenzonitrile 

Downstream Products

• 959841-60-2 5-[(4,5-dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-isopropoxy-benzoic acid 
• 959841-56-6 tert-butyl 4-{5-[(4,5-dimethyl-6-oxo-1,6-dihydro-pyridazin-3-yl)methyl]-2-fluorobenzoyl}-1,4-diazepane-1-carboxylate 
• 959839-57-7 6-[4-Fluoro-3-(4-methyl-2,5-dioxoimidazolidin-1-yl)benzyl]-4,5-dimethyl-3-oxo-2,3-dihydropyridazin-1-ium trifluoroacetate 
• 959840-12-1 4-{5-[(4,5-Dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorobenzoyl}piperazin-1-ium trifluoroacetate 
• 959839-45-3 1-(4-{5-[(4,5-dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorobenzoyl}piperazin-1-yl)-N,2-dimethyl-1-oxo-propan-2-aminium trifluoroacetate 
• 959839-59-9 6-(3-{[3-[1-(Dimethylamino)-1-methylethyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl}-4-fluorobenzyl)-4,5-dimethyl-3-oxo-2,3-dihydropyridazin-1-ium trifluoroacetate 
• 959839-58-8 6-(3-(3-(1-(dimethylamino-1-methylethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)carbonyl)-4-fluorobenzyl)-4,5-dimethyl-3-oxo-2,3-dihydro-pyridazine 
• 959841-58-8 2-(dimethylamino)-5-[(4,5-dimethyl-6-oxo-1,6-dihydro-pyridazin-3-yl)methyl]benzoic acid 
• 959841-65-7 tert-butyl {5-[(4,5-dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorophenyl}carbamate 
• 959839-63-5 6-{4-fluoro-3-[(4-{[1-(isobutylamino)cyclopentyl]carbonyl}piperazin-1-yl)carbonyl]benzyl}-4,5-dimethylpyridazin-3(2H)-one trifluoroacetate 
• 959839-61-3 (2R)-2-[(4-{5-[(4,5-Dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorobenzoyl}piperazin-1-yl)carbonyl]-2-methylazetidinium trifluoroacetate 
• 959841-73-7 tert-Butyl (2R)-2-[(4-{5-[(4,5-dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorobenzoyl}piperazin-1-yl)carbonyl]-2-methylazetidine-1-carboxylate 
• 959841-26-0 6-[3-({4-[(1-aminocyclopentyl)carbonyl]piperazin-1-yl}carbonyl)-4-fluorobenzyl]-4,5-dimethylpyridazin-3(2H)-one 
• 959839-54-4 6-(4-Fluoro-3-{[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl}benzyl)-4,5-dimethylpyridazin-3(2H)-one 

Relevant academic research and scientific papers

Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells

We describe an extensive SAR study in the 6-[4-fluoro-3-(substituted)benzyl]-4,5-dimethylpyridazin-3(2H)-one series which led to the identification of potent PARP-1 inhibitors, capable of inhibiting the proliferation of BRCA-1 deficient cancer cells in th

PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinaldamage, skin senescence and UV-induced skin damage, and as chemo-or radiosensitizers for cancer treatment.

Pyridinone and Pyridazinone Derivatives as Inhibitors of Poly (Adp-Ribose) Polymerase (Parp)

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.