959860-67-4

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 1817-49-8 1,3-diphenyl-1-propyn-3-ol 

Downstream Products

• 1099654-24-6 3-(1,3-diphenylprop-2-ynyl)-4-morpholino-2H-chromen-2-one 
• 1099654-23-5 4-(benzylamino)-3-(1,3-diphenylprop-2-ynyl)-2H-chromen-2-one 
• 10173-87-2 2-(phenyl)-4-(phenyl)pyrano[3,2-c]chromen-5(4H)-one 

Relevant academic research and scientific papers

Regioselective Bismuth-Catalyzed Synthesis of Pyranocoumarins and Furocoumarins from 4-Hydroxycoumarins and Propargyl Alcohols

An efficient method for the bismuth-catalyzed regioselective synthesis of pyranocoumarins and furocoumarins has been developed from the reaction of 4-hydroxycoumarins with propargyl alcohols. The reaction proceeds through sequential propargylation and int

Al(OTf)3-Catalyzed Preparation of 4-Hydroxy-3-propargylic Coumarins and Subsequent Regioselective Cyclization towards Furo- or Pyrano[3,2-c]coumarins

An efficient and economical approach to functionalized furo[3,2-c]coumarin and pyrano[3,2-c]coumarin derivatives has been developed from 4-hydroxy-3-(prop-2-ynyl)coumarin derivatives through organocatalysis or metallo-organocatalysis. Selective '5-exo-dig

Condensation of propargylic alcohols with 1,3-dicarbonyl compounds and 4-hydroxycoumarins in ionic liquids (ILs)

Propargylic alcohols are activated toward 1,3-diketones by Lewis or Br?nsted acidic ionic liquids (ILs) without an added catalyst, but significantly better conversions are achieved with metallic triflates [in particular Sc(OTf)3 and Ln(OTf)sub

Alkylation of 1,3-dicarbonyl compounds with benzylic and propargylic alcohols using Ir-Sn bimetallic catalyst: Synthesis of fully decorated furans and pyrroles

The heterobimetallic complex [Ir(COD)(SnCl3)Cl(μ-Cl)] 2 catalyzes the direct substitution of hydroxyl groups in benzylic and propargylic alcohols by 1,3-dicarbonyl moiety. In 4-hydroxycoumarin, benzylation and propargylation occurs at the 3-position. Selective propargylation or allenylation takes place depending on the nature of propargylic alcohol. By applying the methodology, multi-substituted furans and pyrroles have been synthesized in good yields.

Inexpensive and efficient synthesis of propargylic substituted active methylene compounds catalyzed by FeCl3

A highly efficient and practical method for the synthesis of propargylic substituted 1,3-dicarbonyl compounds with direct use of propargylic alcohols in the presence of inexpensive and environmentally benign FeCl3 (5mol%) has been presented. Th

Tris(pentafluorophenyl)borane-catalyzed alkylation of 1,3-dicarbonyl compounds with benzylic alcohols: Access to oxygenated heterocycles

Tris(pentafluorophenyl)borane has found to be an effective catalyst for the alkylation of 1,3-dicarbonyl compounds using benzylic alcohols as alkylating agents. Various 1,3-dicarbonyl compounds reacted cleanly with different benzylic alcohols to provide t

Molecular iodine-catalyzed C3-alkylation of 4-hydroxycoumarins with secondary benzyl alcohols

A highly efficient method for the C-C bond formation via molecular iodine-catalyzed C3-alkylation reaction of 4-hydroxycoumarins with benzylic, benzhydrylic, allylic, and propargyl alcohols at 50 °C in MeNO2 is described. The 3-alkylated-4-hydr

Solid-supported acid-catalyzed C3-alkylation of 4-hydroxycoumarins with secondary benzyl alcohols: access to 3,4-disubstituted coumarins via Pd-coupling

An efficient and operationally simple method for C3-alkylation of 4-hydroxycoumarins has been developed under acidic medium giving good yields of the products. In the present method, a reusable Amberlite IR-120 (H+ form) was used as an acid catalyst and secondary benzyl alcohols were used as alkylating agents. The obtained 3-alkylated-4-hydroxycoumarins offered an easy access for the synthesis of 3,4-disubstituted coumarins by way of Pd-catalyzed coupling reactions.

Yb(OTf)3-catalyzed propargylation and allenylation of 1,3-dicarbonyl derivatives with propargylic alcohols: one-pot synthesis of multi-substituted furocoumarin

A highly efficient and mild Lewis acid-catalyzed coupling reaction of 1,3-dicarbonyl compounds with propargylic alcohols has been established. Selective propargylation or allenylation products are obtained depending on the nature of propargylic alcohols.