959862-94-3Relevant academic research and scientific papers
Syntheses of LewisX and dimeric LewisX: Construction of branched oligosaccharides by a combination of preactivation and reactivity based chemoselective one-pot glycosylations
Miermont, Adeline,Zeng, Youlin,Jing, Yuqing,Ye, Xin-Shan,Huang, Xuefei
, p. 8958 - 8961 (2007)
(Chemical Equation Presented) Two asymmetrically branched oligosaccharides, LewisX and dimeric LewisX, were assembled in one pot with high yields and exclusive regio- and stereoselectivities. p-Tolyl thioglycosides were utilized as t
Synthesis of the tolerance-inducing oligosaccharide lacto-N-fucopentaose III bearing an activated linker
Zhang, Junfeng,Zou, Lu,Lowary, Todd L.
, p. 156 - 163 (2014/03/21)
A concise synthetic route to an immunomodulatory pentasaccharide, lacto-N-fucopentaose III (1) and its corresponding human serum albumin conjugate, is described. Key transformations of the strategy include two highly regio- and stereoselective glycosylations for the construction of disaccharide 10 and pentasaccharide 12, a Birch reduction for deprotection of benzyl ethers, and a UV-promoted radical addition of a thiol to an alkene for modification of the aglycone.
