95992-27-1Relevant academic research and scientific papers
Thermodynamic and structural characterization of amino acid-linked dialkyl lipids
Tristram-Nagle, Stephanie,Lewis, Ruthven N.A.H.,Blickenstaff, Joseph W.,DiPrima, Michael,Marques, Bruno F.,McElhaney, Ronald N.,Nagle, John F.,Schneider, James W.
, p. 29 - 39 (2007/10/03)
Using differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR), we determined some thermodynamic and structural parameters for a series of amino acid-linked dialkyl lipids containing a glutamic ac
Synthesis and biological activity of N-terminal lipidated and/or fluorescently labeled conjugates of astressin as corticotropin releasing factor antagonists
Rijkers, Dirk T.S.,Den Hartog, Jack A.J.,Liskamp, Rob M.J.
, p. 5099 - 5106 (2007/10/03)
This report describes the synthesis of eight N-terminally modified astressin analogs and their biochemical evaluation as corticotropin releasing factor (CRF) antagonists. The lipidated astressin derivatives were tested on rat CRF receptor type 1 and 2α an
Induction of protein-like molecular architecture by self-assembly processes
Fields, Gregg B.
, p. 75 - 81 (2007/10/03)
One of the most intriguing self-assembly processes is the folding of peptide chains into native protein structures. We have developed a method for building protein-like structural motifs that incorporate sequences of biological interest. A lipophilic moie
Synthetic lipidation of peptides and amino acids: Monolayer structure and properties
Berndt, Peter,Fields, Gregg B.,Tirrell, Matthew
, p. 9515 - 9522 (2007/10/03)
Novel dialkyl chain amphiphiles containing peptides derived from extracellular matrix collagen ligand sequences have been synthesized using a highly efficient solid-phase approach. These compounds have been shown to form stable monolayers at the air-water
Formation of Specific Hydrophobic Sites for Incorporation of Methylene Blue by Laterally Arranged L-Glutamate Residues in Anionic, Crystalline Bilayer Aggregates
Hachisako, Hiroshi,Yamazaki, Tetsuya,Ihara, Hirotaka,Hirayama, Chuichi,Yamada, Kimiho
, p. 1671 - 1680 (2007/10/02)
Bilayer membranes, formed from dioctadecyl L-glutamate-derived anionic amphiphiles, incorporated the cationic dye, methylene blue (MB), into their crystalline, hydrophobic region.The incorporated, monomeric MB was extraordiarily converted into dimeric species during the gel-to-liquid crystalline phase transition by binding to carboxylates.A further increase in temperature upon the phase transition temperature led to the ordinary dimer-to-monomer transition of the bound aggregated MB as well as conventional various dye-polyion systems including micellar systems.However, such extraordinary behaviour strongly depends on the chemical structure of the bilayer-forming component amphiphiles.The molecular structure requirements of anionic amphiphiles for such incorporation has been investigated by varying the alkyl chain length, the average degree of polymerization (x), and the kind of amino acid residue in the connector moiety.Specific incorporation of MB into the crystalline, hydrophobic region is peculiar to molecular assemblies formed from L-glutamte amphiphiles with long alkyl chains and low x values.Corresponding DL-glutamate derivatives showed umbiguous transitions and L-aspartate derivatives did not show such specific incorporation, indicating that the specific behaviour is peculiar to the L-glutamate derivatives.The same conclusion that the monomeric dye species in the crystalline bilayer state is incorporated in the hydrophobic region of the bilayer aggregates could be confirmed by using the solvatochromic dye, 4--N-methylpyridinium iodide (St-4C1), as a microenvironmental probe instead of MB.
