959932-11-7Relevant articles and documents
3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors
Jiang, Rong,Duckett, Derek,Chen, Weiming,Habel, Jeff,Ling, Yuan Yuan,LoGrasso, Philip,Kamenecka, Theodore M.
, p. 6378 - 6382 (2008/09/16)
The structure-based design and synthesis of a novel series of c-Jun N-terminal kinase (JNK) inhibitors with selectivity against p38 is reported. The unique structure of 3,5-disubstituted quinolines (2) was developed from the previously reported 4-(2,7-phenanthrolin-9-yl)phenol (1). The X-ray crystal structure of 16a in JNK3 reveals an unexpected binding mode for this new scaffold with protein.
