959969-87-0Relevant articles and documents
Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCθ inhibitors
Boschelli, Diane H.,Wang, Daniel,Prashad, Amar S.,Subrath, Joan,Wu, Biqi,Niu, Chuan,Lee, Julie,Yang, Xiaoke,Brennan, Agnes,Chaudhary, Divya
, p. 3623 - 3626 (2009)
The key intermediate, 4-chloro-5-iodo-3-pyridinecarbonitrile, allowed for ready optimization of the PKCθ inhibitory activity of a series of 3-pyridinecarbonitriles. Analog 13b with a 4-methylindol-5-ylamino group at C-4 and a 4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl group at C-5 had an IC50 value of 7.4 nM for the inhibition of PKCθ.
