959972-28-2Relevant academic research and scientific papers
Synthesis and PKCθ inhibitory activity of a series of 4-indolylamino-5-phenyl-3-pyridinecarbonitriles
Dushin, Russell G.,Nittoli, Thomas,Ingalls, Charles,Boschelli, Diane H.,Cole, Derek C.,Wissner, Allan,Lee, Julie,Yang, Xiaoke,Morgan, Paul,Brennan, Agnes,Chaudhary, Divya
scheme or table, p. 2461 - 2463 (2009/12/25)
A series of 4-indolylamino-5-phenyl-3-pyridinecarbonitrile inhibitors of PKCθ were synthesized as potential anti-inflammatory agents. The effects of specific substitution on the 5-phenyl moiety and variations of the positional isomers of the 4-indolylamino substituent were explored. This study led to the discovery of compound 12d, which had an IC50 value of 18 nM for the inhibition of PKCθ.
Substituted Cyanopyridines as protein kinase inhibitors
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Page/Page column 21, (2008/06/13)
The present teachings provide compounds of formula I and their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.
