959985-22-9Relevant academic research and scientific papers
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13
Freeman-Cook, Kevin D.,Reiter, Lawrence A.,Noe, Mark C.,Antipas, Amy S.,Danley, Dennis E.,Datta, Kaushik,Downs, James T.,Eisenbeis, Shane,Eskra, James D.,Garmene, David J.,Greer, Elaine M.,Griffiths, Richard J.,Guzman, Roberto,Hardink, Joel R.,Janat, Fouad,Jones, Christopher S.,Martinelli, Gary J.,Mitchell, Peter G.,Laird, Ellen R.,Liras, Jennifer L.,Lopresti-Morrow, Lori L.,Pandit, Jayvardhan,Reilly, Usa D.,Robertson, Donald,Vaughn-Bowser, Marcie L.,Wolf-Gouviea, Lilli A.,Yocum, Sue A.
, p. 6529 - 6534 (2008/09/17)
Explorations in the pyrimidinetrione series of MMP-13 inhibitors led to the discovery of a series of spiro-fused compounds that are potent and selective inhibitiors of MMP-13. While other spiro-fused motifs are hydrolytically unstable, presumably due to e
Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
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, (2008/06/13)
The present invention relates to 5-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said “A” is a 5-7 membered heterocyclic ring as defined in the specification and to pharmaceutical compositions and methods of treating in
