96-79-7

Usage

Uses

Used in Chemical Synthesis:
2''-Chloro-1,1'-dimethyltriethylamine is used as a phase-transfer catalyst for facilitating reactions that require the transfer of a reactant from one phase to another, enhancing the efficiency and speed of certain chemical processes.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 2''-Chloro-1,1'-dimethyltriethylamine serves as a precursor in the synthesis of various drugs, contributing to the development of new medicinal compounds.
Used in Polymer Production:
2''-CHLORO-1,1'-DIMETHYLTRIETHYLAMINE is also utilized in the production of polymers, where it may act as a catalyst or a component in the polymerization process, influencing the properties and performance of the resulting polymers.
Used in Agrochemicals:
2''-Chloro-1,1'-dimethyltriethylamine finds application in the agrochemical sector, potentially as an intermediate in the synthesis of pesticides or other agricultural chemicals, thereby playing a role in crop protection and enhancement.
It is crucial to handle 2''-Chloro-1,1'-dimethyltriethylamine with care due to its corrosive nature, ensuring that it does not come into contact with skin or eyes to prevent harm.

InChI:InChI=1/C8H18ClN/c1-7(2)10(6-5-9)8(3)4/h7-8H,5-6H2,1-4H3

Upstream product

• 96-80-0 2-(diisopropylamino)ethanol 
• 585526-52-9 ethyl ({[bis(propan-2-yl)amino]methyl}sulfanyl)(methyl)phosphinate 
• 107-06-2 1,2-dichloro-ethane 
• 108-18-9 diisopropylamine 

Downstream Products

• 95555-85-4 1-[2-(2-diisopropylamino-ethoxy)-phenyl]-2,5-dimethyl-pyrrole 
• 13347-41-6 xanthene-9-carboxylic acid-(2-diisopropylamino-ethyl ester) 
• 77-11-2 4-diisopropylamino-2,2-diphenyl-butyronitrile 
• 102812-40-8 4-diisopropylamino-2,2-diphenyl-butyric acid dimethylamide 
• 73728-80-0 5-chloro-2-hydroxy-biphenyl-3-carboxylic acid-(2-diisopropylamino-ethyl ester); hydrochloride 
• 6284-67-9 5-bromo-2-hydroxy-biphenyl-3-carboxylic acid-(2-diisopropylamino-ethyl ester); hydrochloride 
• 5456-11-1 2-hydroxy-5-iodo-biphenyl-3-carboxylic acid-(2-diisopropylamino-ethyl ester); hydrochloride 
• 6284-68-0 3-hydroxy-6-iodo-biphenyl-4-carboxylic acid-(2-diisopropylamino-ethyl ester); hydrochloride 
• 67465-68-3 10-<2-Diisopropylamino-aethyl>-4-aza-phenothiazin 
• 31118-38-4 N-[4-(2-Diisopropylamino-ethoxy)-phenyl]-N'-methyl-benzamidine 
• 94681-82-0 α,α-Diethyl-4-chlor-phenylessigsaeure-(2-diisopropylamino-ethylester) 
• 66660-88-6 2-[1-Phenyl-meth-(E)-ylidene]-cyclopentanone O-(2-diisopropylamino-ethyl)-oxime 
• 57227-43-7 N-{2-[4-(2-Diisopropylamino-ethoxy)-phenyl]-1-ethylcarbamoyl-ethyl}-benzamide 
• 27021-43-8 Diisopropyl-(2-phenethyloxy-ethyl)-amine 

Relevant academic research and scientific papers

A versatile and recyclable molecularly imprinted polymer as an oxidative catalyst of sulfur derivatives: A new possible method for mustard gas and v nerve agent decontamination

A molecularly imprinted polymer containing a porphyrin unit was developed as a biomimetic heterogenous catalyst for the oxidation of sulfur derivatives. Its catalytic efficiency under mild conditions and its easy recovery represent a great asset for the design of new decontamination tools for yperite and VX.

Method for synthesizing N,N-diisopropyl-2-chloroethylamine

The invention discloses a method for synthesizing N,N-diisopropyl-2-chloroethylamine. The method comprises the following steps: adding an acid binding agent into an autoclave provided with diisopropylamine and dichloroethane as raw materials and ether as a solvent, and carrying out a synthesis reaction at 80-150 DEG C under 0.7-4.5 MPa for 3-7, wherein a molar ratio of diisopropylamine to dichloroethane is 1:(2-5); and post-processing a product obtained after the synthesis reaction ends in order to obtain highly-pure N,N-diisopropyl-2-chloroethylamine. The method for synthesizing N,N-diisopropyl-2-chloroethylamine has the advantages of simplicity in operation, high yield, and simple post-treatment.

Design, Synthesis, and Biological Evaluation of Scutellarein Derivatives Based on Scutellarin Metabolic Mechanism in Vivo

Three series of scutellarein derivatives have been designed and synthesized based on metabolic mechanism of scutellarin (1) in vivo. Their thrombin inhibition activities were tested through the analyzation of prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FIB). The antioxidant activities of these target products were assessed by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay and the ability to protect PC12 cells against H2O2-induced cytotoxicity, and their solubilities were evaluated by ultraviolet (UV) spectrophotometer. The results showed that the two isopropyl groups substituted derivative (18c) demonstrated stronger anticoagulant activity, better water solubility, and good antioxidant activity compared with scutellarein (2), which warrants further development of 18c as a promising agent for ischemic cerebrovascular disease treatment. Three series of scutellarein derivatives have been designed and synthesized based on metabolic mechanism of scutellarin (1) in vivo. The results of the biological evaluation showed that the two isopropyl groups substituted derivative (18c) demonstrated stronger anticoagulant activity, better water solubility, and good antioxidant activity compared with scutellarein (2), which warrants further development of 18c as a promising agent for ischemic cerebrovascular disease treatment.

Visible-light C-heteroatom bond cleavage and detoxification of chemical warfare agents using titania-supported gold nanoparticles as photocatalyst

Gold nanoparticles supported on TiO2 effect the detoxification of soman and VX nerve gases and yperite vesicant agent at room temperature upon visible light illumination.

Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists

A series of 2,3-disubstituted indenes, which are analogues of the widely used histamine H1 receptor antagonist dimethindene, have been synthesized and studied as muscarinic and histamine receptor antagonists. The affinities of these compounds for the five human muscarinic receptor subtypes (M1-M5) and for human histamine H1 receptors were determined in radioligand binding studies using membranes from transfected Chinese hamster ovary (CHO) cells and [3H]N-methylscopolamine ([3H]NMS). The results demonstrate that the diisopropyl analogue 19 has a similar high affinity as (S)-dimethindene at M2 receptors ((S)-dimethindene: pKi = 7.52; (-)-19: pKi = 7.37) with an improved selectivity pattern ((S)-dimethindene: M2/M1 = 6-fold, M2/M3 = 5-fold, M2/M4 = 10-fold, M2/M5 = 25-fold; (-)-19: M2/M1 = 36-fold, M2/M3 = 96-fold, M2/M4 = 42-fold, M2/M5 = 275-fold). In addition, compound (-)-19 showed 35-fold lower affinity at histamine H1 receptors (pKi = 5.61) than (S)-dimethindene (pKi = 7.16). Another interesting compound is the fluoroethyl derivative 20 (pKi/M2 = 7.49), which also exhibits a higher M2 selectivity (M2/M1 = 19-fold; M2/M3 = 22-fold; M2/M4 13-fold; M2/M5 = 62-fold) than (S)-dimethindene. Unfortunately, compound 20 also shows a high affinity for histamine H1 receptors (pKi = 8.14). The compound with the highest affinity for M2 receptors (pKi = 7.91), the dimethylaminomethylene analogue 31, displayed only a small preference for M2 receptors. In conclusion, compound (-)-19 might be useful to test the hypothesis that blockade of muscarinic M2 receptors in the brain is a viable mechanism by which to produce improved cognition. This second-generation dimethindene analogue might also be the starting point for the development of M2-selective muscarinic antagonists useful for quantifying M2 receptors in the central nervous system with positron emission tomography imaging.