960-61-2Relevant academic research and scientific papers
Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine
Mohamed, Heba A.,Lake, Benjamin R. M.,Laing, Thomas,Phillips, Roger M.,Willans, Charlotte E.
, p. 7563 - 7569 (2015/04/27)
A new library of silver(I)-N-heterocyclic carbene complexes prepared from the natural products caffeine, theophylline and theobromine is reported. The complexes have been fully characterised using a combination of NMR spectroscopy, mass spectrometry, elemental analysis and X-ray diffraction analysis. Furthermore, the hydrophobicity of the complexes has been measured. The silver(I)-N-heterocyclic carbenes have been evaluated for their antiproliferative properties against a range of cancer cell lines of different histological types, and compared to cisplatin. The data shows different profiles of response when compared to cisplatin in the same panel of cells, indicating a different mechanism of action. Furthermore, it appears that the steric effect of the ligand and the hydrophobicity of the complex both play a role in the chemosensitivity of these compounds, with greater steric bulk and greater hydrophilicity delivering higher cytotoxicity.
Direct N9-arylation of purines with aryl halides
Larsen, Anders Foller,Ulven, Trond
supporting information, p. 4997 - 4999 (2014/05/06)
An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N
Selective copper catalysed aromatic N-arylation in water
Engel-Andreasen, Jens,Shimpukade, Bharat,Ulven, Trond
supporting information, p. 336 - 340 (2013/03/14)
4,7-Dipyrrolidinyl-1,10-phenanthroline (DPPhen) was identified as an efficient ligand for copper catalysed selective aromatic N-arylation in water. N-Arylation of indoles, imidazoles and purines proceeds with moderate to excellent yields and complete selectivity over aliphatic amines. Aqueous medium and the possibility for low metal and ligand loadings give the process a benign environmental profile.
Fluorescent phosphoinositide 3-kinase inhibitors suitable for monitoring of intracellular distribution
Kim, Donghee,Lee, Hyunseung,Jun, Hwiseok,Hong, Soon-Sun,Hong, Sungwoo
experimental part, p. 2508 - 2516 (2011/06/17)
The monitoring of the drug behavior and distribution in biological system can provide information whether drug reaches its desired target, and a biological rationale for the design of new therapeutics. We have developed a family of potent fluorescent PI3K
Copper nanoparticle-doped silica cuprous sulfate as a highly efficient and reusable heterogeneous catalysis for N-arylation of nucleobases and N-heterocyclic compounds
Soltanirad, Mohammad Navid,Behrouz, Somayeh,Doroodmand, Mohammad Mahdi,Moghtaderi, Noushin
experimental part, p. 3915 - 3924 (2012/01/03)
A facile and simple protocol for Ullmann-type N-arylation of nucleobases with aryl halides is described using copper nanoparticle-doped silica cuprous sulfate (CN-DSCS) as a new and efficient heterogeneous catalysis. In this method, treatment of various n
