960-99-6Relevant academic research and scientific papers
Synthesis of α-Amidoketones from Vinyl Esters via a Catalytic/Thermal Cascade Reaction
Holthusen, Katharina,Leitner, Walter,Franciò, Giancarlo
, p. 4823 - 4828 (2016)
A straightforward, modular, and atom-efficient method is reported for the synthesis of α-amidoketones from vinyl esters via a cascade reaction including hydroformylation, condensation with a primary amine, and a rearrangement step giving water as the only byproduct. The reaction sequence can be performed in one pot or as a three-step procedure. The synthetic applicability is demonstrated by the preparation of different α-amidoketones in moderate to good yields.
