96000-13-4

Upstream product

• 96000-12-3 20-<<oxy>methyl>-4-methyl-4-aza-5α-pregnan-3-one 
• 882-33-7 diphenyldisulfane 
• 86283-92-3 20-(hydroxymethyl)-4-methyl-5-α-4-azapregnan-3-one 

Downstream Products

• 96000-15-6 20-(hydroxymethyl)-4-methyl-4-aza-5α-pregn-1-en-3-one 
• 96021-28-2 (4aR,4bS,6aS,7R,9aS,9bS,11aR)-3-Benzenesulfonyl-7-(2-hydroxy-1-methyl-ethyl)-1,4a,6a-trimethyl-hexadecahydro-indeno[5,4-f]quinolin-2-one 
• 96021-29-3 (4aS,4bS,6aS,7R,9aS,9bS,11aR)-3-Benzenesulfinyl-7-(2-hydroxy-1-methyl-ethyl)-1,4a,6a-trimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-indeno[5,4-f]quinolin-2-one 

Relevant academic research and scientific papers

Preparation of 20-(hydroxymethyl)-4-methyl-4-aza-2-oxa-5α-pregnan-3-one as an inhibitor of testosterone 5α-reductase

20-(Hydroxymethyl)-4-methyl-4-aza-2-oxa-5α-pregnan-3-one and the corresponding 3-thione were synthesized with use of 20-(hydroxymethyl)-4- methyl-4-aza-5α-pregnan-3-one as the starting material. The compounds were tested in vitro for inhibition of testosterone 5α-reductase and found to be weak inhibitors with K(i)'s in the 10-7 range.