960005-03-2Relevant academic research and scientific papers
A microarray strategy for mapping the substrate specificity of protein tyrosine phosphatase
Koehn, Maja,Gutierrez-Rodriguez, Marta,Jonkheijm, Pascal,Wetzel, Stefan,Wacker, Ron,Schroeder, Hendrik,Prinz, Heino,Niemeyer, Christof M.,Breinbauer, Rolf,Szedlacsek, Stefan E.,Waldmann, Herbert
, p. 7700 - 7703 (2008/09/19)
Which substrate will it be? Phosphotyrosine peptide microarrays have allowed the substrate specificity to be mapped for two prototypical protein-tyrosine phosphatases (PTPs): PTP1B and PTPμ. The knowledge gained was used for molecular docking studies (see picture: the docking of a peptide in the binding pocket of PTPμ) and the design of an inhibitor for PTPμ. (Figure Presented).
