960010-13-3Relevant academic research and scientific papers
A selective chemical probe for coenzyme A-requiring enzymes
Hwang, Yousang,Thompson, Paul R.,Wang, Ling,Jiang, Lihua,Kelleher, Neil L.,Cole, Philip A.
, p. 7621 - 7624 (2007)
(Chemical Equation Presented) Tagging transferases: A coenzyme A (CoA)-based affinity probe with a sulfoxycarbamate functionality can selectively identify several acetyltransferases relative to other enzymes and proteins. It leaves behind a desthiobiotin tag that can be used for western blotting and mass spectrometric characterization (see picture; Nu = nucleophile).
