960013-15-4Relevant academic research and scientific papers
ω-Alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: A study of chain-length and stereochemical dependence
Hanessian, Stephen,Auzzas, Luciana,Giannini, Giuseppe,Marzi, Mauro,Cabri, Walter,Barbarino, Marcella,Vesci, Loredana,Pisano, Claudio
, p. 6261 - 6265 (2007)
A series of ω-alkoxy ethers were prepared with variation of the length of the aliphatic chain of suberoylanilide hydroxamic acid (SAHA, vorinostat). Eight carbon long chain analogues showed the best activity, among which several substituted benzyl ether d
AMIDE COMPOUNDS AND THEIR USE AS ANTITUMOR AGENTS
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Page/Page column 79, (2008/12/07)
The present invention relates to a compound of Formula (I), its geometrical isomers, in an optically active form as enantiomers, diastereomers, as well as in the form of racemate, as well as pharmaceutically acceptable salts thereof, wherein R is selected from CONHOH, CONHCH2SH, CONHCH2SCOCH3, SH, SCOCH3, SCH3, N(OH)COH, COCONHCH3 and CF3for the preparation of a medicament, in particular for for selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells, for inducing differentiation of tumor cells in a tumor, for inhibiting the activity of histone deacetylase and for the treatment of primary cancer or secondary cancer.
