960050-90-2Relevant academic research and scientific papers
Enantioselective 1,3-dipolar cycloaddition of cyclic enones catalyzed by multifunctional primary amines: Beneficial effects of hydrogen bonding
Chen, Wei,Du, Wei,Duan, Yong-Zheng,Wu, Yong,Yang, Sheng-Yong,Chen, Ying-Chun
, p. 7667 - 7670 (2008/09/18)
(Chemical Equation Presented) Hydrogen bonding makes a difference: Multifunctional primary amine catalysts derived from cinchona alkaloids are used in the highly enantioselective 1,3-dipolar cycloaddition of cyclic enones and azomethine imines (see scheme; R = aryl, alkyl; TIPBA = 2,4,6- triisopropylbenzene-sulfonic acid). The synergistic hydrogen-bonding interaction of catalyst and 1,3-dipole is essential for stereocontrol.
