960062-75-3

Upstream product

• 960061-71-6 C₅₄H₅₅N₁₃O₁₀S₆ 
• 960062-66-2 C₄₉H₄₇N₁₃O₈S₆ 
• 960062-73-1 C₅₀H₄₇N₁₃O₉S₆ 
• 960061-69-2 C₄₈H₄₃N₁₅O₈S₆ 
• 960062-64-0 C₄₈H₄₄N₁₂O₉S₆ 
• 960061-70-5 C₅₂H₅₃N₁₃O₉S₆ 
• 960062-74-2 C₅₀H₄₅N₁₃O₈S₆ 
• 2920-08-3 ethyl isocyanopropionate 
• 2999-46-4 Ethyl isocyanoacetate 

Downstream Products

• 960062-76-4 C₅₄H₅₁N₁₅O₁₀S₆ 
• 960062-05-9 C₅₁H₄₆N₁₄O₉S₆ 
• 960062-07-1 C₅₃H₄₉N₁₅O₁₀S₆ 

Relevant academic research and scientific papers

4-Aminothiazolyl analogs of GE2270 A: Design, synthesis and evaluation of imidazole analogs

Imidazole analogs of the antibiotic natural product GE2270 A (1) were designed, synthesized, and evaluated for Gram positive bacteria growth inhibition. A recently reported, copper-mediated synthesis was exploited to prepare 4-thiazolyl imidazole analogs

Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: Identification of the cycloalkylcarboxylic acids

4-Aminothiazolyl analogues of the antibiotic natural product GE2270 A (1) were designed, synthesized, and optimized for their activity against Gram positive bacterial infections. Optimization efforts focused on improving the physicochemical properties (e.g., aqueous solubility and chemical stability) of the 4-aminothiazolyl natural product template while improving the in vitro and in vivo antibacterial activity. Structure-activity relationships were defined, and the solubility and efficacy profiles were improved over those of previous analogues and 1. These studies identified novel, potent, soluble, and efficacious elongation factor-Tu inhibitors, which bear cycloalkylcarboxylic acid side chains, and culminated in the selection of development candidates amide 48 and urethane 58.

EFTU INHIBITORS OR AMINOTHIAZOLES AND THEIR USES

The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.