960065-33-2Relevant academic research and scientific papers
First supramolecular sensors for phosphonate anions
Esipenko, Nina A.,Koutnik, Petr,Minami, Tsuyoshi,Mosca, Lorenzo,Lynch, Vincent M.,Zyryanov, Grigory V.,Anzenbacher, Pavel
, p. 3617 - 3623 (2013/11/19)
Fluorescent tripodal anion sensors with a 1,3,5-triethylbenzene core display a turn-on fluorescence response to phosphonate and phosphate anions and may be used as optical sensors. The properties of the receptors and sensors as well as their anion binding behavior were investigated both in solution and in solid state. The turn-on fluorescence response can be leveraged in sensing of phosphate anions and, most importantly, hydrolysis products of the nerve gas sarin, isopropyl methylphosphonate (IMP), and methylphosphonate (MP). The fluorescence signal amplification in the presence of anions allows for application of these molecules in a sensor microarray suitable for high-throughput screening.
Rational design of a fluorescence-turn-on sensor array for phosphates in blood serum
Zyryanov, Grigory V.,Palacios, Manuel A.,Anzenbacher Jr., Pavel
, p. 7849 - 7852 (2008/09/18)
Getting turned on: An order-of-magnitude fluorescence amplification of simple tripodal sensors has been observed in the presence of phosphate ions. An X-ray structure analysis of one of the complexes (see picture) shows the binding of three phosphate ions, which closely resembles the anionic part of ATP, by the sensor. The sensors were used to generate cross-reactive arrays that can detect anions in human serum. (Figure Presented).
