960137-89-7Relevant academic research and scientific papers
A microwave-assisted domino benzannulation reaction towards functionalized naphthalenes, quinolines, and isoquinolines
Wang, Yuqin,Tan, Cun,Zhang, Xiaofei,He, Qian,Xie, Yuyuan,Yang, Chunhao
, p. 6622 - 6629,8 (2012)
An efficient palladium/copper-catalyzed domino reaction was developed to yield functionalized naphthalenes, quinolines, and isoquinolines. The reactions of various substituted 1-phenylprop-2-yn-1-ols containing electron-donating (EDG) and electron-withdrawing (EWG) groups and 1-heteroarylprop-2-yn-1-ols worked well with this procedure. Both electron-rich and-deficient aryl halides were satisfactory substrates for this reaction. This domino benzannulation process involves a Sonogashira cross-coupling reaction, followed by isomerization to a chalcone, and finally an intramolecular condensation reaction.
A convergent synthesis of polysubstituted aromatic nitriles via palladium-catalyzed C-H functionalization
Mariampillai, Brian,Alliot, Julien,Li, Mengzhou,Lautens, Mark
, p. 15372 - 15379 (2008/09/18)
A palladium-catalyzed C-H functionalization reaction for the synthesis of highly substituted aromatic nitriles is reported. The modularity of the reaction is demonstrated by the broad range of aryl iodides which can be coupled with metal cyanides and alkyl halides or aryl bromides.
