96020-49-4Relevant academic research and scientific papers
Total Synthesis of Escherichia coli Lipid A, the Endotoxically Active Principle of Cell-Surface Lipopolysaccharide
Imoto, Masahiro,Yoshimura, Hiroyuki,Shimamoto, Tetsuo,Sakaguchi, Nobuki,Kusumoto, Shoichi,Shiba, Tetsuo
, p. 2205 - 2214 (2007/10/02)
Chemical synthesis are described of polyacylated β(1->6) glucosamine disaccharide 1,4'-bis(phosphate), which corresponds to the proposed structure of E. coli lipid A, and of its dephospho derivatives.The synthetic bisphosphate proved to be identical with
TOTAL SYNTHESIS OF ESCHERICHIA COLI LIPID A
Imoto, Masahiro,Yoshimura, Hiroyuki,Sakaguchi, Nobuki,Kusumoto, Shoichi,Shiba, Tetsuo
, p. 1545 - 1548 (2007/10/02)
The first total synthesis of E. coli lipid A (1) is described.The synthetic compound was identical with a natural specimen and exhibited the full endotoxic activity.It was thus conclusively proved by this chemical synthesis that lipid A is the active prin
