960203-28-5

Usage

Uses

Used in Pharmaceutical Research and Development:
1-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine Hydrochloride is utilized as a research compound for exploring its potential pharmacological effects. It is particularly valuable in the early stages of drug discovery and development, where its properties can be assessed for various therapeutic applications.
Used in Psychoactive Substance Research:
In the field of psychopharmacology, 1-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine Hydrochloride is used as a subject of study to understand its impact on the central nervous system. Its potential as a psychoactive substance is of interest to researchers looking to develop new treatments for neurological and psychiatric disorders.
Used in Treatment of Medical Conditions:
Depending on the outcomes of research, 1-[2-(2,4-DiMethylphenylsulfanyl)phenyl]piperazine Hydrochloride may be employed as a therapeutic agent for the treatment of certain medical conditions. Its specific application would be determined by the nature of the condition and the compound's demonstrated efficacy and safety in clinical studies.

Upstream product

• 508233-74-7 vortioxetine 
• 110-85-0 piperazine 
• 367-11-3 ortho-difluorobenzene 
• 13616-82-5 2,4-dimethyl-thiophenol 
• 59084-06-9 1-(2-nitrophenyl)piperazine 
• 199105-17-4 2-(4-benzylpiperazin-1-yl)aniline 
• 199105-16-3 1-benzyl-4-(2-nitrophenyl)piperazine 
• 583-53-9 2,3-dibromobenzene 
• 583-55-1 1-Bromo-2-iodobenzene 
• 960203-41-2 (2′-bromophenyl)(2,4-dimethylphenyl)sulfane 
• 1019453-85-0 2-(2,4-dimethylphenylsulphanyl)benzeneamine 
• 1429908-35-9 1-(2-((2,4-dimethylphenyl)sulfinyl)phenyl)piperazine 
• 88-73-3 2-Chloronitrobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 508233-74-7 vortioxetine 
• 960203-27-4 Vortioxetine hydrobromide 

Relevant academic research and scientific papers

PROCESS AND NOVEL POLYMORPHIC FORM OF VORTIOXETINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

Processes are disclosed for making vortioxetine and pharmaceutically acceptable salts thereof. A propylene glycol solvate of vortioxetine hydrobromide is disclosed. A novel crystalline form of vortioxetine hydrobromide propylene glycol solvate, designated form AC1, is disclosed along with a method for making same. Form AC1 may be characterized by an x-ray powder diffraction pattern with peaks at about 19.64, 22.85, 25.51, 29.57, 30.18±0.2 degrees 2-theta.

AN IMPROVED PROCESS FOR THE PREPARATION OF VORTIOXETINE AND SALTS THEREOF

The present invention relates to a novel crystalline polymorphic form of 1-[2-(2,4-dimethyl- phenylsulfanyl)-phenyl]-piperazine hydrochloride; commonly known as vortioxetine hydrochloride (hereafter referred to as the compound (Ia) and process for its preparation comprising of treating the compound (Ia) (as described herein) with a ketone solvent or mixture of ketone solvent with other solvents. The present invention also relates to an improved process for the preparation of vortioxetine hydrobromide (Ia), comprising reacting the compound (I) (as described herein) with hydrogen bromide solution in acetic acid.

AN IMPROVED PROCESS FOR PREPARATION AND PURIFICATION OF VORTIOXETINE HYDROBROMIDE

The present invention is related to an improved process for the preparation and purification of crystalline polymorph of Vortioxetine hydrobromide of Formula-I and Vortioxetine hydrochloride of Formula-Ia. The process according to present invention is operationally simple and suitable for industrial application which will avoid hazardous chemicals and eliminate column chromatography to get ICH quality of pharmaceutically acceptable active pharmaceutical ingredient having snow white appearance.

1-[2-(2,4-dimethylphenylsulfydryl)phenyl]piperazine hydrochloride and preparation method thereof

The invention discloses 1-[2-(2,4-dimethylphenylsulfydryl)phenyl]piperazine hydrochloride and a preparation method thereof. By means of the specific preparation method, the HPLC purity of vortioxetinehydrochloride is higher than 99.5%, and the content of

PROCESS FOR THE PREPARATION OF VORTIOXETINE AND SALTS THEREOF

The present invention provides an improved process for preparation of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine; commonly known as vortioxetine (referred to as the compound (I)) and pharmaceutically acceptable salts thereof; wherein the process comprises reaction of 2-((2,4-dimethylphenyl)thio)aniline (II) with bis(2-alkyl)amine (IIIa) or its salt in the presence of a cyclic amide solvent.

Hydrochloric acid [...][...] crystalline hydrochloride monohydrate and its preparation method

The invention discloses a vortioxetine hydrochloride crystal substance and a preparation method thereof, including three new crystal forms of vortioxetine hydrochloride and preparation methods thereof and application to preparation of medicines for treati

Mechanism and Scope of Base-Controlled Catalyst-Free N-Arylation of Amines with Unactivated Fluorobenzenes

A general method for transition metal-free N-arylation of amines has been developed. Mechanistic studies have revealed that the ability of the base to facilitate the desired amination without promoting unwanted side reactions is the guiding factor. By employing lithium bis(trimethylsilyl)amide as a base the resultant deprotonated amines readily react with a range of unactivated fluorobenzene derivatives. This new arylation method is utilized for the simple two-step synthesis of the antidepressant Vortioxetine.

A PROCESS FOR PREPARATION OF VORTIOXETINE AND POLYMORPHS THEREOF

The present invention relates to an improved process for preparation of vortioxetine or pharmaceutically acceptable salts thereof. The present invention also relates to new process for the preparation of vortioxetine or pharmaceutically acceptable salts thereof. The present invention further relates to novel polymorphs of vortioxetine hydrobromide and process for preparation thereof.

PROCESSES FOR THE PREPARATION OF VORTIOXETINE HYDROBROMIDE

The present invention relates to a process for the preparation of vortioxetine and its pharmaceutically acceptable salts.

SYNTHESIS OF VORTIOXETINE VIA (2-(PIPERAZINE-1 -YL)PHENYL)ANILINE INTERMEDIATES

The present invention provides a new synthetic process for the production of 1-(2-((2,4- dimethylphenyl)thio)phenyl)piperazine (vortioxetine), a drug for the treatment of depression and anxiety, which is conducted via (2-(piperazine-1-yl)phenyl)aniline intermediates.