960315-75-7Relevant academic research and scientific papers
Efficient asymmetric synthesis of silanediol precursors from 1,5-dihydrosiloles
Sen, Sushmita,Purushotham, Madhusudhan,Qi, Yingmei,Sieburth, Scott McN.
, p. 4963 - 4965 (2007)
Dihydrosiloles are easily prepared from 1,3-dienes and dichlorosilanes, even on kilogram scale. Asymmetric hydroboration of a 3-alkyl-1,5-dihydrosiloie, prepared from a 2-alkyl-1,3-diene, followed by treatment with aqueous HF results in Peterson fragmentation, forming optically active 3-alkyl-4- fluorosilyl-1-butenes. The fluorosilanes are stable to moisture but very reactive toward nucleophiles. In addition, they can be converted to nucleophilic silyllithium reagents.
