960318-64-3Relevant academic research and scientific papers
Rhodium-catalyzed asymmetric rearrangement of alkynyl alkenyl carbinols: Synthetic equivalent to asymmetric conjugate alkynylation of enones
Nishimura, Takahiro,Katoh, Taisuke,Takatsu, Keishi,Shintani, Ryo,Hayashi, Tamio
, p. 14158 - 14159 (2008/09/18)
Asymmetric 1,3-rearrangement of an alkynyl group of alkynyl alkenyl carbinols giving β-alkynylketones took place in high yields with high enantioselectivity in the presence of a hydroxyrhodium/(R)-binap catalyst. The present method including a key β-alkynyl elimination step in the catalytic cycle is synthetically equivalent to the asymmetric conjugate addition of terminal alkynes to β-substituted enones. Copyright
