960401-35-8

Upstream product

• 101469-92-5 (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 3251-56-7 2-methoxy-4-nitrophenol 
• 132945-75-6 (S)-tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate 

Downstream Products

• 960401-43-8 (R)-tert-butyl 3-(4-amino-2-methoxyphenoxy)pyrrolidine-1-carboxylate 
• 1574542-90-7 (R)-tert-butyl 3-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-methoxyphenoxy)pyrrolidine-1-carboxylate 
• 1574538-55-8 (R)-3-(4-cyclopropylphenoxy)-1-(3-methoxy-4-(pyrrolidin-3-yloxy)phenyl)-1H-pyrrol-2(5H)-one hydrochloride 

Relevant academic research and scientific papers

PYRROLONE OR PYRROLIDINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS

The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are melanin concentrating hormone receptor-1 (MCHR1) antagonists which may be used as medicaments.

NOVEL MCH RECEPTOR ANTAGONISTS

The present invention relates to a melanin concentrating hormone antagonist compound of formula (I): wherein R1, Ra, Rb, R2, L1, R3, R4 and R5 are as defined, or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture of diasteromers thereof useful in the treatment, obesity and related diseases.