960403-37-6Relevant articles and documents
An enantioselective route to α-methyl carboxylic acids via metal and enzyme catalysis
Norinder, Jakob,Bogar, Krisztian,Kanupp, Lisa,Baeckvall, Jan-E.
, p. 5095 - 5098 (2007)
Dynamic kinetic resolution of allylic alcohols to allylic acetates followed by copper-catalyzed allylic substitution gave alkenes in high yields and high optical purity. Subsequent oxidative C-C double bond cleavage afforded pharmaceutically important α-methyl substituted carboxylic acids in high ee.