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Relevant academic research and scientific papers

One dimensional CdS nanostructures: Heterogeneous catalyst for synthesis of aryl-3,3′-bis(indol-3-yl)methanes

Herein, we have developed a novel heterogeneous catalytic system for synthesis of bis(indol-3-yl)methanes using one dimensional (1D) CdS nanorods. CdS nanorods were synthesized by a solvothermal reaction technique at 200 °C over 12 h in the presence of et

Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates

A series of bisindole-pyrrolobenzodiazepine conjugates (5a-f) linked through different alkane spacers was prepared and evaluated for their anticancer activity. All compounds exhibited significant anticancer potency and the most potent compounds 5b and 5e

Optimization of novel oxidative DIMs as Nur77 modulators of the Nur77-Bcl-2 apoptotic pathway

Nur77, an orphan nuclear receptor, is a member of the nuclear receptor superfamily. Nur77 plays important roles in various biological processes. Previously we reported that BI1071(DIM-C-pPhCF3+MeSO3-), an oxidiz

3-Amino-5-mercapto-1,2,4-triazole-functionalized Fe3O4 magnetic nanocomposite as a green and efficient catalyst for synthesis of bis(indolyl)methane derivatives

A core–shell Fe3O4?silica magnetic nanocomposite functionalized with 3-amino-5-mercapto-1,2,4-triazole (Fe3O4/SiO2/PTS/AMTA) was prepared using Fe3O4 with silica layer, and its s

COMPOUNDS AND USES THEREOF

A pharmaceutical composition is described herein, including an antimicrobial agent and a compound having Formula A, or Formula B. Methods of using the pharmaceutical compositions to treat microbial infection are also described.

Synthesis, anti-methicillin-resistant S. aureus (MRSA) evaluation, quantitative structure-activity relationship and molecular modeling studies of some novel bis-indoles as prospective MRSA pyruvate kinase

Background: MRSA is a gram positive pathogen resistant to methicillin and other betalactam antibiotics, including penicillin, oxacillin, and declooxacillin. Statistical data suggest that as many as 19,000 people per year die from MRSA in the USA. Methods:

BF3-grafted Fe3O4@Sucrose nanoparticles as a highly-efficient acid catalyst for syntheses of Dihydroquinazolinones (DHQZs) and Bis 3-Indolyl Methanes (BIMs)

Current paper represents immobilization of sucrose on the Fe3O4 core and grafting of boron trifluoride (BF3) onto the new surface. The catalytic activity of these nanoparticles was tested in syntheses of Dihydroquinazolinones (DHQZs) and Bis (3-Indolyl) Methanes (BIMs) as two fruitful pharmaceutical structures. Acidic capacity, FT-IR, XRD, VSM, TGA and SEM–EDX tests are carried out on such novel nanoparticles (NPs). Catalyst has shown more acidic capacity per one gram of NPs than sulfonated homologue which was reported previously.

Preparation of immobilized hexamine on Fe3O4/SiO2 core/shell nanoparticles: a novel catalyst for solvent-free synthesis of bis(indolyl)methanes

Abstract: Hexamethylenetetramine covalently immobilized on silica-coated magnetic nanoparticles is prepared and characterized by XRD, FT-IR, SEM, and VSM. According to SEM pictures, the nanoparticles are mostly spherical in shape, and their size is approximately 46?nm. The catalytic performance of these magnetic nanoparticles for the synthesis of bis(indolyl)methanes was investigated. The catalyst was readily recycled by the use of an external magnetic field and can be reused four times without significant loss of activity. Graphical Abstract: [Figure not available: see fulltext.]

Synthesis and characterization of Polyindole and its catalytic performance study as a heterogeneous catalyst

The catalytic performance study of polyindole as a heterogeneous catalyst is reported for the synthesis of 3,3'-arylmethylene-bis-1H-Indole derivatives using various substituted aldehydes and indole under reflux reaction condition with good to excellent y

Sulfonic acid-functionalized magnetic nanoparticles as a recyclable and eco-friendly catalyst for atom economical Michael addition reactions and bis indolyl methane synthesis

A modified sulfonic acid functionalized magnetic nanoparticle composite (Fe3O4@γFe2O3-SO3H) is prepared by the use of ultrasonic irradiation. By this modification, the size of the nano-particles was r