960600-91-3Relevant academic research and scientific papers
Enantioselective synthesis of substituted indanones from silyloxyallenes
Brekan, Jonathan A.,Reynolds, Troy E.,Scheidt, Karl A.
supporting information; experimental part, p. 1472 - 1473 (2010/04/03)
(Chemical Equation Presented) A new approach for the synthesis of enantioenriched indanones by asymmetric carbonyl-ene/intramolecular Heck cyclization from racemic silyloxyallenes has been developed. The modular procedure affords highly substituted indenes and indanones with excellent chirality transfer from the optically active carbinols. Full transfer of stereochemical information is achieved in the presence of 1,2,2,6,6- pentamethylpiperidine and PdCl2(PPh3)2 (1 mol %) in DMF under microwave heating. Short reaction times and high yields have been demonstrated on a variety of substrates. Copyright
Catalytic enantioselective α-acylvinyl anion reactions of silyloxyallenes
Reynolds, Troy E.,Scheidt, Karl A.
, p. 7806 - 7809 (2008/09/19)
(Chemical Equation Presented) Alternatives with silicon: The enantioselective Lewis acid catalyzed addition of racemic silyloxyallenes to aldehydes is reported. A {(salen)CrIII} complex efficiently catalyzes the reaction of these α-acylvinyl an
