960607-56-1

Usage

Uses

Used in Organic Synthesis:
(3-BROMO-1,4-DIMETHOXY-NAPHTHALEN-2-YL)-ACETALDEHYDE is used as a building block in organic synthesis for creating more complex chemical structures. Its unique structure allows for the formation of various derivatives, making it a versatile compound in the field of organic chemistry.
Used in Drug Development and Medicinal Chemistry:
(3-BROMO-1,4-DIMETHOXY-NAPHTHALEN-2-YL)-ACETALDEHYDE is used as a research tool in the study of drug development and medicinal chemistry. Its potential biological activity and chemical properties make it a valuable compound for exploring new drug candidates and understanding their mechanisms of action.
Used in Pharmaceutical Production:
(3-BROMO-1,4-DIMETHOXY-NAPHTHALEN-2-YL)-ACETALDEHYDE is used as a reagent in the production of pharmaceuticals. Its chemical properties allow it to be incorporated into the synthesis of various drug molecules, contributing to the development of new medications and therapies.
Used in Chemical Research:
(3-BROMO-1,4-DIMETHOXY-NAPHTHALEN-2-YL)-ACETALDEHYDE is used in chemical research to study its properties and potential applications. Researchers can use (3-BROMO-1,4-DIMETHOXY-NAPHTHALEN-2-YL)-ACETALDEHYDE to investigate its reactivity, stability, and interactions with other molecules, leading to a better understanding of its potential uses and limitations in various fields.

InChI:InChI=1/C14H13BrO3/c1-17-13-9-5-3-4-6-10(9)14(18-2)12(15)11(13)7-8-16/h3-6,8H,7H2,1-2H3

Upstream product

• 114200-92-9 3-bromo-1,4-dimethoxy-2-naphthaleneacetonitrile 
• 80089-60-7 2-allyl-3-bromo-1,4-dimethoxy-naphthalene 
• 2065-37-4 2-bromo-1,4-naphthoquinone 
• 64648-81-3 2-bromo-1,4-dimethoxynaphthalene 
• 86489-90-9 2-bromo-3-(2-bromomethyl)-1,4-dimethoxynaphthalene 

Downstream Products

• 161363-76-4 2-[1,4-Dimethoxy-3-(2-oxo-ethyl)-naphthalene-2-carbonyl]-benzoic acid methyl ester 
• 161363-75-3 2-(3-[1,3]Dioxolan-2-ylmethyl-1,4-dimethoxy-naphthalene-2-carbonyl)-benzoic acid 
• 404908-62-9 3-bromo-2-(2-hydroxypropyl)-1,4-dimethoxynaphthalene 

Relevant academic research and scientific papers

Enantioselective synthesis of an analogue of nanaomycin A

The enantioselective synthesis of (1R,3R)-deoxynanaomycin A (4) is reported. The key step involves introduction of the Stereocenter in (S)-homoallylic alcohol 10a using an asymmetric allylation of aldehyde 9. Lithium-halogen exchange of bromo acetate 11 triggered rapid intramolecular cyclization furnishing lactol 12 that underwent silane-mediated reduction providing (1R,3S)-naphthopyran 13. Dihydroxylation and oxidative cleavage gave aldehyde 15 that underwent two successive oxidations delivering (1R,3R)-deoxynanaomycin A (4) in high enantiopurity and an overall 7% yield over 12 steps from 1-naphthol (5). Georg Thieme Verlag Stuttgart.

Palladium catalyzed intramolecular cascade type cyclizations: Interesting Approach towards naphthoquinone derivatives having an O-containing heterocyclic skeleton

Important naphthoquinones fused with an O-containing six-, seven- and eight-membered ring along with one tetracyclic compound, which are normally difficult to construct, have been synthesized using intramolecular Heck reaction where 6-exo trig, 7-endo trig and 8-endo trig cyclizations take place, respectively.

Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone

The asymmetric synthesis of (-)-9-demethoxyeleutherin 6, (+)-9-demethoxyeleutherin 7 and (+)-7,9-deoxythysanone 8 has been achieved using a microwave assisted kinetic resolution of racemic alcohol 11 with Novozyme 435 as the key step.

The synthesis of radermachol

Five different approaches to the preparation of 6,7-benzo-3,4-(1,4-dimethoxy-2,3-naphtho)-1,5-dioxosuberane (3), an intermediate needed for the synthesis of radermachol (1), the red pigment from the roots of Radermachera xylocarpa, are described. The synthesis of radermachol (1) has been accomplished from 1,4-naphthoquinone in 14 steps.