96096-65-0Relevant academic research and scientific papers
Enantioselective Synthesis of Pyrroloindolines via Noncovalent Stabilization of Indole Radical Cations and Applications to the Synthesis of Alkaloid Natural Products
Gentry, Emily C.,Rono, Lydia J.,Hale, Martina E.,Matsuura, Rei,Knowles, Robert R.
supporting information, p. 3394 - 3402 (2018/03/13)
While interest in the synthetic chemistry of radical cations continues to grow, controlling enantioselectivity in the reactions of these intermediates remains a challenge. Based on recent insights into the oxidation of tryptophan in enzymatic systems, we
On a facile synthesis of melatonin and other related indoles
Marais, Wilhelmina,Holzapfel, Cedric W.
, p. 3681 - 3691 (2007/10/03)
An efficient laboratory synthesis for melatonin and other related indoles utilising enamides and enecarbamates is described.
Psychotomimetic N-Methyl-N-isopropyltryptamines. Effects of Variation of Aromatic Oxygen Substituents
Repke, David B.,Grotjahn, Douglas B.,Shulgin, Alexander T.
, p. 892 - 896 (2007/10/02)
Eight N-methyl-N-isopropyltryptamines (MIPTs) possessing various aromatic oxygen substituents were prepared, characterized, and evaluated for hallucinogenic activity in man.In at least two instances (the Ar H and the Ar 5-OCH3, 1 and 4) the unsymmetrical nitrogen substitution led to a substantial increase in potency as well as oral activity when compared to the symmetrical dimethyl homologues.Qualitatively, 4-hydroxy-N-methyl-N-isopropyltryptamine (2) was the most interesting in overall effect, producing a classic hallucinogenic profile.The 5-methoxy congeger 4 resulted in a state characterized by heightened conceptual stimulation lacking in visual phenomena.Other members of the series exhibited diminished effects.
