96101-27-8

Usage

Uses

Used in Pharmaceutical Applications:
[1,2,4]Triazino[4,5-a]benzimidazol-1(2H)-one,4-methyl-(9CI) is used as a pharmaceutical compound for its demonstrated biological activity. [1,2,4]Triazino[4,5-a]benzimidazol-1(2H)-one,4-methyl-(9CI) and its derivatives are being studied for their potential properties in the development of new drugs, particularly due to their unique structure and molecular composition.
Used in Chemical Research:
In the field of chemical research, [1,2,4]Triazino[4,5-a]benzimidazol-1(2H)-one,4-methyl-(9CI) serves as a valuable synthetic target. Its distinctive structure and molecular composition make it an interesting subject for further exploration and experimentation, potentially leading to the discovery of new compounds and advancements in the field.
Used in Drug Development:
[1,2,4]Triazino[4,5-a]benzimidazol-1(2H)-one,4-methyl-(9CI) is also utilized in drug development, where its biological activity and unique structure contribute to the creation of novel therapeutic agents. Researchers are investigating the potential of [1,2,4]Triazino[4,5-a]benzimidazol-1(2H)-one,4-methyl-(9CI) and its derivatives to develop new drugs with improved efficacy and reduced side effects.

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 939-70-8 2-acetylbenzimidazole 
• 96101-26-7 2-acetylbenzimidazole hydrazone 
• 96101-28-9 2-acetylbenzimidazole ethoxycarbonylhydrazone 
• 541-41-3 chloroformic acid ethyl ester 

Relevant academic research and scientific papers

Cascade reactions of nitrogen-substituted isocyanates: A new tool in heterocyclic chemistry

In contrast to normal C-substituted isocyanates, nitrogen-substituted isocyanates (N-isocyanates) are rare. Their high reactivity and amphoteric/ambident nature has prevented the scientific community from exploiting their synthetic potential. Recently, we have developed an in situ formation approach using a reversible equilibrium, which allows controlled generation and reactivity of N-isocyanates and prevents the dimerization that is typically observed with these intermediates. This blocked (masked) N-isocyanate approach enables the use of various N-isocyanate precursors to assemble heterocycles possessing the N-N-CO motif, which is often found in agrochemicals and pharmaceuticals. Cascade reactions for the rapid assembly of several valuable 5- and 6-membered heterocycles are reported, including amino-hydantoins, acyl-pyrazoles, acyl-phthalazinones and azauracils. Over 100 different compounds were synthesized using amino-, imino- and amido-substituted N-isocyanates, demonstrating their potential as powerful intermediates in heterocyclic synthesis. Their reactivity also enables access to unprecedented bicyclic derivatives and to substitution patterns of azauracils that are difficult to access using known methods, illustrating that controlled reactivity of N-isocyanates provides new disconnections, and a new tool to assemble complex N-N-CO containing motifs.

Benzimidazoles. Part 2. A New Synthesis of Triazinobenzimidazol-1-ones

Reaction of 2-acetylbenzimidazole (8a) with ethyl carbazate gives the substituted hydrazone (9a).When this or the simple hydrazone (11a,b,c) is heated with ethyl chloroformate in pyridine, cyclization to the title compound (12) occurs.Cyclization of the p