96102-27-1

Usage

Uses

Used in Nucleic Acid Synthesis:
TFA-aa-dC is used as a protected precursor for the controlled and efficient addition of deoxycytidine to the growing DNA chain during nucleic acid synthesis. The trifluoroacetic acid protection enhances the stability and solubility of the compound, allowing for precise and reliable DNA synthesis.
Used in Research and Biotechnology Applications:
TFA-aa-dC is utilized in various research and biotechnology applications that require the chemical synthesis of DNA. Its use ensures the accurate and efficient construction of DNA sequences, which is essential for studying genetic information, developing new therapies, and creating innovative biotechnological products.
Used in Drug Development:
In the pharmaceutical industry, TFA-aa-dC is employed in the development of new drugs that target genetic disorders or diseases. Its role in DNA synthesis allows for the creation of specific DNA sequences that can be used to study the mechanisms of action of potential therapeutic agents and to develop targeted treatments.
Used in Diagnostics:
TFA-aa-dC is also used in the development of diagnostic tools that rely on DNA synthesis, such as DNA probes and qPCR assays. These tools are essential for detecting and monitoring various diseases and conditions, as well as for genetic testing and analysis.
Used in Synthetic Biology:
In the field of synthetic biology, TFA-aa-dC is employed in the design and construction of synthetic DNA sequences for various applications, including the creation of novel biological systems, the development of biofuels, and the production of biomaterials. Its use in DNA synthesis enables the precise assembly of genetic information, facilitating the advancement of synthetic biology research and applications.

Upstream product

• 952292-38-5 C₁₇H₃₂F₃NOSn 
• 611-53-0 5-Iodo-2'-deoxycytidine 

Relevant academic research and scientific papers

PYRAZOLE-TYPE CYANINE DYE

PROBLEM Provided is a novel cyanine dye derivative with a pyrazole skeleton and an indole skeleton, having high sensitivity performance in a shorter wavelength region as compared with a conventional optical system, and showing high water solubility. SOLUTION The invention provides (1) a compound represented by the following general formula [50] and a salt thereof: [wherein R1 to R6 each independently represent a substituted or unsubstituted alkyl group which may have an amide bond; R7 to R10 each independently represent alkyl group, alkenyl group, alkynyl group, aryl group, alkoxy group, aryloxy group, alkylthio group, arylthio group, alkylsulfonyl group, arylsulfonyl group, carbamoyl group, sulfamoyl group, ureido group or amino group, those groups being able to have substituents; a group represented by the general formula [2] : ????????-COOR12?????[2] (wherein R12 represents hydrogen atom, C1 to C10 alkyl group, alkali metal atom, organic ammonium ion, ammonium ion or anion); a group represented by the general formula [3]: ????????-SO3R13?????[3] (wherein R13 represents hydrogen atom, alkali metal atom, organic ammonium ion, ammonium ion or anion), halogen atom, aromatic heterocyclic thio group, hydrogen atom, hydroxyl group, cyano group, formyl group, thiol group or nitro group; R11 represents hydrogen atom, or alkyl group, alkenyl group, alkynyl group or aryl group, those groups being able to have substituents; and n represents an integer of from 0 to 3, provided that any of R1 and R2, R4 and R5, R1 and R6, and R2 and R4 may form a bivalent group with a group selected from -O- group, -S- group, -COO-group and groups represented by the general formulae [52] to [54]: (wherein R50 represents hydrogen atom, alkyl group, alkenyl group or aryl group, those groups being able to have substituents), and substituted or unsubstituted alkylene group; and in the case where said bivalent group is formed, at least one of R1 to R11, along with the bivalent group formed by any of R1 and R2, R4 and R5, R1 and R6, and R2 and R4, has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group; and in the case where said bivalent group is not formed, at least one of R1 to R11 has the group represented by the general formula [2], the group represented by the general formula [3], amino group, hydroxyl group, thiol group or formyl group]; (2) a labeled compound obtained by subjecting the above compound to direct or indirect binding to a substance to be labeled, and (3) a method for labeling a substance to be labeled, comprising subjecting the above compound to direct or indirect binding to the substance to be labeled.