96129-46-3

Upstream product

• 536-74-3 phenylacetylene 
• 14337-43-0 ethyl 2-chloro-2-(hydroxyimino)acetate 
• 18315-80-5 ethyl α-nitrocinnamate 
• 127919-48-6 t-butyl [2-(4-phenyl-3-isoxazolecarboxamido)ethyl]carbamate 
• 53983-15-6 ethyl-5-amino-4-phenyl-isoxazole-3-carboxylate 

Downstream Products

• 127919-48-6 t-butyl [2-(4-phenyl-3-isoxazolecarboxamido)ethyl]carbamate 
• 403860-31-1 3-hydroxymethyl-4-phenylisoxazole 

Relevant academic research and scientific papers

Monofluorinated 5-membered ringsviafluoromethylene transfer: synthesis of monofluorinated isoxazolineN-oxides

The synthesis of five-membered rings using fluoromethylene transfer chemistry is an attractive method for building fluorinated products of high value. This work demonstrates for the first time that one-fluorine-one-carbon modification of a substrate could

INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES

This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.

COMPOUNDS FOR TREATING AND PREVENTING COGNITIVE DISEASES AND DEPRESSION AND METHODS OF MAKING SAME

Ethylenediamine monoamides of the formula R--CO--NH--CH2 --CH2 --NH2. wherein R is one of groups in which R1 is phenyl monohalophenyl, monolower-alkylphenyl, monolower-alkoxypheynl, monotrifluoromethylphenyl, monocyanophenyl or monoaryl-lower-alkoxyphenyl, dihalophenyl, furyl, thienyl or monohalothienyl, R2 is hydrogen, halogen or amino, R3, R5 and R7 each are phenyl, monohalophenyl, dihalophenyl, thienyl, furyl or monohalofuryl, R4 and R6 each are hydrogen or amino and R8 is hydrogen or lower-alkyl, as well as their pharmaceutically usable acid addition salts are disclosed. The compounds have monoamine oxidase inhibiting properties with low toxicity and are useful for the treatment of depressive states and cognitive disorders

Alkynes from 5-Aminoisoxazoles

Diazotization of 5-aminoisoxazoles that bear at least one electron-withdrawing group by reaction with sodium nitrite in AcOH-H2O affords substituted acetylenes.A reaction path is proposed.