96187-53-0Relevant academic research and scientific papers
Design, Synthesis, and Characterization of Brequinar Conjugates as Probes to Study DHODH Inhibition
Madak, Joseph T.,Cuthbertson, Christine R.,Chen, Wenmin,Showalter, Hollis D.,Neamati, Nouri
, p. 13875 - 13878 (2017/09/18)
Brequinar, a potent dihydroorotate dehydrogenase (DHODH) inhibitor, has been evaluated in multiple clinical trials as a potential treatment for cancer. To further understand brequinar-based DHODH inhibition and DHODH′s therapeutic relevance in cancer, we
COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING HEMATOLOGICAL CANCERS
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Page/Page column 54; 55, (2017/03/28)
The present invention includes methods of treating patients with acute myeloid leukemia across a range of genetic subtypes with DHODH inhibitors, such as 6-fluoro-2-(2'-fluoro-[1,1'- biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid).
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
Sykes, David B.,Kfoury, Youmna S.,Mercier, Fran?ois E.,Wawer, Mathias J.,Law, Jason M.,Haynes, Mark K.,Lewis, Timothy A.,Schajnovitz, Amir,Jain, Esha,Lee, Dongjun,Meyer, Hanna,Pierce, Kerry A.,Tolliday, Nicola J.,Waller, Anna,Ferrara, Steven J.,Eheim, Ashley L.,Stoeckigt, Detlef,Maxcy, Katrina L.,Cobert, Julien M.,Bachand, Jacqueline,Szekely, Brian A.,Mukherjee, Siddhartha,Sklar, Larry A.,Kotz, Joanne D.,Clish, Clary B.,Sadreyev, Ruslan I.,Clemons, Paul A.,Janzer, Andreas,Schreiber, Stuart L.,Scadden, David T.
, p. 171 - 15,186 (2016/09/28)
While acute myeloid leukemia (AML) comprises many disparate genetic subtypes, one shared hallmark is the arrest of leukemic myeloblasts at an immature and self-renewing stage of development. Therapies that overcome differentiation arrest represent a power
4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents
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, (2008/06/13)
4-Quinolinecarboxylic acids and derivatives thereof, such as 2-(2'-fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, are useful as immunomodulatory and anti-inflammatory agents. Pharmaceutical formulations containing such compounds are useful for the treatment of autoimmune diseases, organ transplantation rejection, graft vs. host disease, multiple sclerosis, and chronic inflammatory diseases such as rheumatoid arthritis.
4-quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases
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, (2008/06/13)
Phenylquinolinecarboxylic acids and derivatives thereof, such as 2-(2'-Fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, or a sodium or potassium salt thereof, are useful for the treatment of skin and muco-epithelial diseases.
2-phenyl-4-quinolinecarboxylic acids and pharmaceutical compositions thereof
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, (2008/06/13)
Phenylquinolinecarboxylic acids and derivatives thereof, such as 2-(2'-fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinolinecarboxylic acid, or a sodium or potassium salt thereof, are useful as tumor inhibiting agents.
