96187-75-6

Basic information

• Product Name: 6-CHLORO-5-METHYLISATIN
• Synonyms: 6-CHLORO-5-METHYLISATIN;6-CHLORO-5-METHYLISA;6-chloro-5-methyl-1H-indole-2,3-dione
• CAS NO: 96187-75-6
• Molecular Formula: C₉H₆ClNO₂
• Molecular Weight: 195.6
• Product Categories: Indane/Indanone and Derivatives
• Mol File: 96187-75-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-CHLORO-5-METHYLISATIN(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-5-METHYLISATIN(96187-75-6)
• EPA Substance Registry System: 6-CHLORO-5-METHYLISATIN(96187-75-6)

Safety Data

• Hazardous Substances Data: 96187-75-6(Hazardous Substances Data)

Usage

General Description

6-Chloro-5-methylisatin is a chemical compound with the molecular formula C9H7ClO2. It is a derivative of isatin, a yellowish crystalline compound found in various plants and bacteria. 6-Chloro-5-methylisatin has potential applications in the pharmaceutical industry, where it can be used as a precursor in the synthesis of various pharmaceutical drugs. It is also known for its biological activity, particularly as a potential anti-cancer and anti-inflammatory agent. The compound has been the subject of research into its potential therapeutic properties and has shown promising results in various studies.

Upstream product

• 95-74-9 3-chloro-p-toluidine 
• 7745-89-3 3-chloro-4-methylaniline hydrochloride 
• 155184-79-5 N-(3-chloro-4-methyl-phenyl)-2-hydroxyimino-acetamide 

Downstream Products

• 155184-81-9 2-amino-5-methyl-4-chlorobenzoic acid 

Relevant articles and documents

Synthesis of substituted tryptanthrin via aryl halides and amines as antitumor and anti-MRSA agents

The natural alkaloid, tryptanthrin (indolo[2,1-b]quinazoline-6,12-dione), and its analogues are found to exhibit potent antitumor and anti-MRSA activities. An efficient and convenient method has been developed for the synthesis of tryptanthrin D-ring derivatives through the reaction of substituted tryptanthrins and secondary amines in moderate to good yields. Some of the new compounds exhibited antitumor activities against the human tumor cell lines A549, HCT116 and MDA-MB-231, with mean IC50 values at low micromolar levels. In addition, some of the compounds showed excellent anti-MRSA activities and were more effective than vancomycin, with MIC values of 0.31–1.25 μg/mL for Mu50,RN4220, and Newman strains.