962-58-3

Basic information

• Product Name: DIAZINON-O-ANALOG
• Synonyms: diethyl (6-methyl-2-propan-2-yl-pyrimidin-4-yl) phosphate;diethyl (6-methyl-2-propan-2-ylpyrimidin-4-yl) phosphate;phosphoric acid diethyl (2-isopropyl-6-methyl-pyrimidin-4-yl) ester;Diazinon-O-analog 100mg [962-58-3];Diazinon oxon, 100 μg /μL in acetone;DIAZINON-O-ANALOG;DIAZINON OXON;Diazoxon
• CAS NO: 962-58-3
• Molecular Formula: C12H21N2O4P
• Molecular Weight: 288.28
• Mol File: 962-58-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 335.8°Cat760mmHg
• Flash Point: 156.9°C
• Appearance: /
• Density: 1.141g/cm³
• Vapor Pressure: 0.000228mmHg at 25°C
• Refractive Index: 1.484
• PKA: 1.21±0.30(Predicted)
• CAS DataBase Reference: DIAZINON-O-ANALOG(CAS DataBase Reference)
• NIST Chemistry Reference: DIAZINON-O-ANALOG(962-58-3)
• EPA Substance Registry System: DIAZINON-O-ANALOG(962-58-3)

Safety Data

• RIDADR: 3018
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 962-58-3(Hazardous Substances Data)

Usage

Definition

ChEBI: An organic phosphate that is diethyl hydrogen phosphate in which the hydrogen of the hydroxy group has been replaced by a 6-methyl-2-(propan-2-yl)pyrimidin-4-yl group. It is a metabolite of the pesticide diazinon.

InChI:InChI=1/C12H21N2O4P/c1-6-16-19(15,17-7-2)18-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3

Upstream product

• 333-41-5 `Diazinon` 
• 814-49-3 diethyl chlorophosphate 

Relevant articles and documents

Oxidation of diazinon by aqueous chlorine: Kinetics, mechanisms, and product studies

The oxidation kinetics and mechanisms of diazinon, an organophosphorus pesticide, by aqueous chlorine were studied under different conditions. The oxidation is of first order with respect to both diazinon and chlorine. The oxidation rate is found to increase with decreasing pH. The second-order rate constants at pH 9.5, 10.0, 10.5, and 11.0 are determined to be 1.6, 0.64, 0.43, and 0.32 M-1 s-1, respectively. Based on the rate constants at different temperatures, the activation energy is calculated to be 30 kJ/mol at pH 10.0 with a chlorine-to-diazinon ratio of 11:1, 33 kJ/mol at pH 11.0 with a 11:1 ratio, and 36 kJ/mol at pH 11.0 with a 5:1 ratio, respectively. Diazoxon is identified as the oxidation product by GC-MS. Ion chromatography analysis shows an increase of sulfate concentration as the reaction proceeds, indicating that sulfur is being oxidized to sulfate. This study indicates that oxidation by aqueous chlorine can significantly affect the fate of diazinon in the environment.

Oxidation of organophosphorus pesticides for the sensitive detection by a cholinesterase-based biosensor

A potentiometric flow injection-type biosensor developed in our laboratory was used for the determination of organophosphorus pesticides (OPs). The principle of the biosensor is that the degree of inhibition of a sensor enzyme by an OP is dependent on the concentration of the pesticide. The sensor system consisted of a reactor with acetylcholinesterase (AChE) immobilized on a controlled pore glass and a detector with a tubular H+-selective membrane electrode. In order to examine the possibility of enhancing the sensitivity of the sensor by converting OPs to oxidized forms (stronger inhibitors), a comparison of the degree of enzyme inhibition by OPs at 10-6 M before and after their oxidation was made. All of the ten pesticides tested exhibited greater inhibitory power toward the sensor enzyme following oxidation. All of the oxidized pesticides at 10-6 M inhibited the sensor enzyme to a considerable degree, demonstrating the utility of the developed method for the class-specific determination of OPs. A calibration curve for diazinon, over the concentration range of 10-11-10-4 M, was obtained. The lower detection limit was 2 × 10-10 M. Treatment of the inhibited enzyme with pyridine-2-aldoxime restored the enzyme to near full activity, allowing repeated use of the sensor,