96212-85-0Relevant academic research and scientific papers
Process development for a large scale stereoselective synthesis of (Z)-(1-bromobut-1-ene-1,2-diyl)dibenzene, a key intermediate of a selective estrogen receptor modulator
Cann, Reginald O.,Waltermire, Robert E.,Chung, Jihchin,Oberholzer, Matthew,Kasparec, Jiri,Ye, Yun K.,Wethman, Robert
experimental part, p. 1147 - 1152 (2011/04/16)
Two efficient large scale syntheses of (Z)-(1-bromobut-1-ene-1,2-diyl) dibenzene are described. The first is a three-step synthetic sequence from trimethyl(phenylethynyl)silane in 63% overall yield. The key transformations involved the stereospecific carb
Stereospecific Synthesis of (Z)-Tamoxifen via Carbometalation of Alkynylsilanes
Miller, R. Bryan,Al-Hassan, Mohammed I.
, p. 2121 - 2123 (2007/10/02)
A sterospecific synthesis of (Z)-tamoxifen, a tetrasubstituted alkene with antiestrogenic activity, is described.The key reaction that establishes the olefin stereochemistry is a carbometalation of phenyl(trimethylsilyl)acetylene with diethylaluminum chloride-titanocene dichloride.A key intermediate that would lead to (E)-tamoxifen was also prepared in an analogous stereospecific manner.
