96212-87-2Relevant articles and documents
DEVELOPMENT OF NEW SELECTIVE ESTROGEN RECEPTOR MODULATORS
-
Page/Page column 27-28, (2010/02/11)
The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs
Synthesis of cis- and trans-tamoxifen
Al-Hassan, Mohammed I.
, p. 1247 - 1252 (2007/10/02)
The synthesis of cis-tamoxifen, non antiestrogenic tetrasubstituted olefin, was achieved via carboalumination of diphenylacetylene as a key step.Conversion to the antiestrogenic trans-tamoxifen was achieved by facile cis-trans isomerization of the corresponding phenol by acid or catalysts.