96226-11-8Relevant academic research and scientific papers
Air-assisted addition of grignard reagents to olefins. A simple protocol for a three-component coupling process yielding alcohols
Nobe, Youhei,Arayama, Kyohei,Urabe, Hirokazu
, p. 18006 - 18007 (2005)
Silylmethyl, tertiary-alkyl, alkenyl, and aryl Grignard reagents underwent intermolecular addition to olefins, such as styrenes, conjugated dienes, and enynes under an air atmosphere to give homologated alcohols. For example, (trimethylsilyl)methylmagnesi
1,2-Dialkylation of 1,1-Arylboryl Alkenes Via Borata-Alkene Intermediate
González, Sara,Salvado, Oriol,Fernández, Elena
supporting information, p. 1701 - 1707 (2022/04/12)
We describe here the conjugate addition of tert-butyllithium to vinyl systems of boronic esters to generate a borata-alkene intermediate, followed by a sequential SN2 reaction with alkyl halides, at room temperature. We envisioned this goal through engaged C(sp3) chemical entities avoiding metal catalysts, additives, radical initiators or specific irradiation. This reaction guarantees that the new tetrasubstituted carbon formed retains all the C atoms from the three starting materials involved in the assembly. (Figure presented.).
Multicomponent Oxyalkylation of Styrenes Enabled by Hydrogen-Bond-Assisted Photoinduced Electron Transfer
Tlahuext-Aca, Adrian,Garza-Sanchez, R. Aleyda,Glorius, Frank
supporting information, p. 3708 - 3711 (2017/03/21)
Herein, we disclose a strategy for the activation of N-(acyloxy)phthalimides towards photoinduced electron transfer through hydrogen bonding. This activation mode enables efficient access to C(sp3)-centered radicals upon decarboxylation from bench-stable and readily available substrates. Moreover, we demonstrate that the formed alkyl radicals can be successfully employed in a novel redox-neutral method for constructing sp3?sp3 bonds across styrene moieties that gives straightforward access to complex alcohol and ether scaffolds.
Solvolysis of 2-aryl-2-chloro-4,4-dimethylpentanes. Confirmation of validity of brown-okamoto σ+ constants
Takeuchi,Takasuka,Ohga,Okazaki
, p. 2375 - 2380 (2007/10/03)
Specific rate constants of solvolysis in 90% aqueous acetone have been determined at 25 °C for 10 2-aryl-2-chloro-4,4-dimethylpentanes (3) having a substituent p-cycPr, p-Me, m-Me, p-F, (H), p-Cl, m-Cl, m-CF3, p-CF3, or p- NO2/
