96238-45-8

Basic information

• Product Name: 2-Propenenitrile,3-(1-methyl-1H-pyrrol-2-yl)-,(Z)-(9CI)
• Synonyms: 2-Propenenitrile,3-(1-methyl-1H-pyrrol-2-yl)-,(Z)-(9CI)
• CAS NO: 96238-45-8
• Molecular Formula: C8H8N2
• Molecular Weight: 0
• Product Categories: AMINETERTIARY
• Mol File: 96238-45-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenenitrile,3-(1-methyl-1H-pyrrol-2-yl)-,(Z)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenenitrile,3-(1-methyl-1H-pyrrol-2-yl)-,(Z)-(9CI)(96238-45-8)
• EPA Substance Registry System: 2-Propenenitrile,3-(1-methyl-1H-pyrrol-2-yl)-,(Z)-(9CI)(96238-45-8)

Safety Data

• Hazardous Substances Data: 96238-45-8(Hazardous Substances Data)

Upstream product

• 1192-58-1 N-methylpyrrole aldehyde 
• 16640-68-9 cyanomethylene triphenylphosphorane 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 

Relevant articles and documents

Synthesis of polyenylpyrrole derivatives with selective growth inhibitory activity against T-cell acute lymphoblastic leukemia cells

T-cell acute lymphoblastic leukemia (T-ALL) is a hardly curable disease with a high relapse rate. 20 analogs were synthesized based on the structures of two kinds of fungi-derived polyenylpyrrole products (rumbrin (1) and auxarconjugatin-B (2)) to suppress the growth of T-ALL-derived cell line CCRF-CEM and tested for growth-inhibiting activity. The octatetraenylpyrrole analog gave an IC50 of 0.27 μM in CCRF-CEM cells, while it did not affect Burkitt lymphoma-derived cell line Raji and the cervical cancer cell line HeLa, or the oral cancer cell line HSC-3 (IC50 > 10 μM). This compound will be a promising compound for developing T-ALL-specific drugs.

Utilisation of 13C N.M.R. Spectroscopy for the Identification of E- and Z-α,β-Unsaturated Esters, Ketones and Nitriles.

Measurement of 3JCO,H coupling constants provides an unambiguous procedure for the configurational analysis of substituted 2- and 3-arylpropenoic esters and of E- and Z-2-arylbut-2-en-1,4-dioates, even when only one of the isomers is available for analysis.An analogous procedure can also be used for the configurational analysis of 3-arylpropenonitriles and of 4-arylbut-3-en-2-ones.