96238-45-8Relevant academic research and scientific papers
Synthesis of polyenylpyrrole derivatives with selective growth inhibitory activity against T-cell acute lymphoblastic leukemia cells
Yoshida, Chihiro,Higashi, Tomoya,Hachiro, Yoshifumi,Fujita, Yuki,Yagi, Takuya,Takechi, Azusa,Nakata, Chihiro,Miyashita, Kazuya,Kitada, Nobuo,Saito, Ryohei,Obata, Rika,Hirano, Takashi,Hara, Takahiko,Maki, Shojiro A.
supporting information, (2021/02/27)
T-cell acute lymphoblastic leukemia (T-ALL) is a hardly curable disease with a high relapse rate. 20 analogs were synthesized based on the structures of two kinds of fungi-derived polyenylpyrrole products (rumbrin (1) and auxarconjugatin-B (2)) to suppress the growth of T-ALL-derived cell line CCRF-CEM and tested for growth-inhibiting activity. The octatetraenylpyrrole analog gave an IC50 of 0.27 μM in CCRF-CEM cells, while it did not affect Burkitt lymphoma-derived cell line Raji and the cervical cancer cell line HeLa, or the oral cancer cell line HSC-3 (IC50 > 10 μM). This compound will be a promising compound for developing T-ALL-specific drugs.
Rhodium(II) catalyzed intramolecular insertion of carbenoids derived from 2-pyrrolyl and 3-indolyl α-diazo-β-ketoesters and α-diazoketones
Cuevas-Ya?ez, Erick,Muchowski, Joseph M.,Cruz-Almanza, Raymundo
, p. 1505 - 1511 (2007/10/03)
α-Diazo-β-ketoesters and α-diazoketones derived from 2-pyrrolylacetic, 2-pyrrolylpropionic, 3-indolylacetic and 3-indolylpropionic acids afforded carbenoid derived cyclization products on treatment with catalytic rhodium(II) acetate.
Utilisation of 13C N.M.R. Spectroscopy for the Identification of E- and Z-α,β-Unsaturated Esters, Ketones and Nitriles.
Gregory, Barrie,Hinz, Werner,Jones, R. Alan,Arques, Jose Sepulveda
, p. 2801 - 2821 (2007/10/02)
Measurement of 3JCO,H coupling constants provides an unambiguous procedure for the configurational analysis of substituted 2- and 3-arylpropenoic esters and of E- and Z-2-arylbut-2-en-1,4-dioates, even when only one of the isomers is available for analysis.An analogous procedure can also be used for the configurational analysis of 3-arylpropenonitriles and of 4-arylbut-3-en-2-ones.
