96243-68-4

Upstream product

• 123-54-6 acetylacetone 
• 72345-23-4 (2S,4S)-pentane-2,4-diol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 125518-43-6 tetrakisbisphosphine 
• 131019-73-3 (2R,4R)-2,4-bispentane 
• 96183-46-9 ((2R,4R)-(-)-2,4-bis(diphenylphosphine)pentane) 
• 827310-80-5 (2R,4R)-2,4-bis(3-bromophenoxy)pentane 
• 869958-63-4 1,2,4,6,8,9-hexamethyl-3,7-diphenyl-5,6-dihydro-4H-3a,6a-diphospha-cyclopenta[e]azulene 
• 1047661-31-3 C₄₉H₅₂I₂O₄P₂ 
• 1192675-27-6 (2R,4R)-2,4-bis(2-iodide-3-nitrophenoxyl)pentane 
• 496042-36-5 [(2R,4R)-6-iodo-2,4-dimethyl-3,4-dihydro-2H-1,5-benzodioxepin-7-yl](diphenyl)phosphine oxide 
• 496042-35-4 [(2R,4R)-2,4-dimethyl-3,4-dihydro-2H-1,5-benzodioxepin-7-yl](diphenyl)phosphine oxide 
• 496042-34-3 (2,4-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-diphenyl-phosphane 

Relevant academic research and scientific papers

Rhodium(I)-Catalyzed Intermolecular Hydroacylation of α-Keto Amides and Isatins with Non-Chelating Aldehydes

The application of the bidentate, electron-rich bisphosphine ligand, 1,3-bis(dicyclohexyl)phosphine-propane (dcpp), in rhodium(I)-catalyzed intermolecular ketone hydroacylation is herein described. Isatins and α-keto amides are shown to undergo hydroacylation with a variety of non-chelating linear and branched aliphatic aldehydes. Also reported is the synthesis of new bidentate chiral phosphine ligands, and their application in hydroacylation is discussed.

Synthesis of Novel Diastereomeric Diphosphine Ligands and Their Applications in Asymmetric Hydrogenation Reactions

(Matrix Presented) Diastereomeric biaryl diphosphine ligands 10 and 11 with added chiral centers on the backbone were synthesized. Substrate-directed asymmetric synthesis occurred in the coupling step of the preparation of the diastereomeric diphosphine oxides. The diastereomeric diphosphine oxides were easily separated by column chromatography with silica gel. Ruthenium catalysts containing these ligands were highly effective in the hydrogenation of 2-(6′-methoxy-2′-naphthyl)propenoic acid and β-ketoesters. The additional chiral centers had a significant influence on the enantioselectivity and activity of the catalysts.

An Asymmetric Hydrogenation Sysytem Breeding Its Own Counter-configurated Ligand

A homogeneous catalytic system based on Ruthenium-Skewphos complexes is presented, which breeds enantioselectively a precursor for the synthesis of Skewphos.In contrast to the known "self breeding" system of Prophos, this system generates the precursor for the opposite enantiomer of the ligand to enable access to both enantiomer of Skewphos after one and two cycles, respectively.

An Efficient Procedure for the Synthesis of C-Chiral Bisphosphines.

A practical method for the synthesis of bisphosphines containing homochiral carbon backbones is described.This procedure entails sequential reaction of a homochiral ditosylate with the appropriate dialkyl- or diarylphosphine-borane anion followed by BH3 decomplexation mediated by HBF4*OMe2.

A FACILE METHOD FOR THE PREPARATION OF 2,4-BIS(DIPHENYLPHOSPHINO)PENTANE(BDPP) ENENTIOMERS AND THEIR APPLICATION IN ASYMMETRIC HYDROGENATION

Asymmetric heterogeneous hydrogenation of acetylacetone was applied for the preparation of both enantiomers (2R,4R and 2S,4S) of 2,4-bis(diphenylphosphino)pentane (BDPP).Among the chiral phosphine prepared up to now BDPP appears to be unique in the sense that its rhodium(I) complexes serve as effective homogeneous asymmetric hyrogenation catalysts not only for the reduction Z-α-amidoacrylic acids but also for the reduction of α-ethylstyrene, acetophenone, and acetophenonebenzylimine.The analogous phosphinite ligand BDPOP yields a less active catalyst