96245-87-3 Usage
Uses
Used in Medicinal Chemistry and Drug Development:
1-(2-deoxy-beta-ribofuranosyl)-5-bromo-2-pyrimidinone is used as a potential antiviral or antineoplastic agent in the field of medicinal chemistry and drug development. Its unique structure allows it to be studied for its therapeutic effects against various viral and neoplastic conditions.
Used in Antiviral Applications:
In the pharmaceutical industry, 1-(2-deoxy-beta-ribofuranosyl)-5-bromo-2-pyrimidinone is used as an antiviral agent for its potential to inhibit viral replication and reduce the severity of viral infections.
Used in Antineoplastic Applications:
1-(2-deoxy-beta-ribofuranosyl)-5-bromo-2-pyrimidinone is also used as an antineoplastic agent, where it may be explored for its potential to inhibit the growth and proliferation of cancer cells, offering a novel therapeutic approach to cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 96245-87-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,2,4 and 5 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 96245-87:
(7*9)+(6*6)+(5*2)+(4*4)+(3*5)+(2*8)+(1*7)=163
163 % 10 = 3
So 96245-87-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H11BrN2O4/c10-5-2-11-9(15)12(3-5)8-1-6(14)7(4-13)16-8/h2-3,6-8,13-14H,1,4H2/t6-,7+,8?/m0/s1
96245-87-3Relevant academic research and scientific papers
Synthesis and Biological Activities of 2-Pyrimidinone Nucleosides. 2. 5-Halo-2-pyrimidinone 2'-Deoxyribonucleosides
Efange, Simon M. N.,Alessi, Elaine M.,Shih, H. C.,Cheng, Yung-Chi,Bardos, Thomas J.
, p. 904 - 910 (2007/10/02)
1-(2-Deoxy-β-D-ribofuranosyl)-5-bromo-2-pyrimidinone (BrPdR) and 1-(2-deoxy-β-D-ribofuranosyl)-5-iodo-2-pyrimidinone (IPdR) have been synthesized by condensation of the appropriate silylated bases 2a and 2b, respectively, with 3,5-bis-O-(p-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride (8) in 1,2-dichloroethane, in the presence of SnCl4, followed by separation of the anomeric blocked nucleosides via column chromatography and subsequent deprotection with methanolic ammonia.Both BrPdR and IPdR exhibited significant antiherpes activities against various strains of HSV-1 and HSV-2, the latter compound (IPdR) showing the higher activity as well as the stronger binding to the virus-specific thimidine kinase.
