96256-50-7

Upstream product

• 186581-53-3 diazomethane 
• 772-62-3 3,3,3-trifluoro-1-phenylpropyne 
• 63156-74-1 2-methyl-4-phenyl-5-trifluoromethyl-2H-pyrazol-3-ylamine 
• 60-34-4 methylhydrazine 
• 185389-51-9 (E)-3-phenyl-4-diethylamino-1,1,1-trifluorobut-3-en-2-one 
• 497832-99-2 4-bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazole 
• 98-80-6 phenylboronic acid 
• 139746-19-3 4,4,4-Trifluoro-3,3-dihydroxy-2-phenyl-butyronitrile 

Relevant academic research and scientific papers

Intermolecular Palladium(0)-Catalyzed Atropo-enantioselective C-H Arylation of Heteroarenes

Atropisomeric (hetero)biaryls are motifs with increasing significance in ligands, natural products, and biologically active molecules. The straightforward construction of the stereogenic axis by efficient C-H functionalization methods is extremely rare an

Synthesis of trifluoromethylated pyrazoles from trifluoromethylenaminones and monosubstituted hydrazines

Cyclocondensation of monosubstituted hydrazines 2a-c with trifluoromethylenaminones 1a-c afforded 3-CF3 and (or) 5-CF3 pyrazoles 3-6. Addition of N-methylhydrazine to enaminone led to 3-CF3 pyrazole as the major product, w

4-Substituted 5-Amino-1-methyl-3-trifluoromethylpyrazoles: Structural Determination by Means of Carbon-13 Nuclear Magnetic Resonance Spectrometry

Regioselective formation of 5-amino-4-aryl-1-methyl-3-trifluoromethylpyrazoles from 3-oxo-2-aryl-4,4,4-trifluorobutanenitrile and methylhydrazine was confirmed by 13C NMR spectrometry.

Studies on Organic Fluorine Compounds. XLII. Synthesis and Reactions of Phenyltrifluoromethylacetylenes

Phenyltrifluoromethylacetylene (4a) was synthesized by the pyrolysis of triphenylphosphonium α-(trifluoroacetyl)benzylide (3a), which was easily derived from benzyl halide (1a).This method can be used for the synthesis of 4-substituted-phenyltrifluoromethylacetylenes (4).The 1,3-dipolar reaction of 4 with diazomethane and phenyl azide proceeds readily to give trifluoromethylated pyrazoles and triazoles.Keywords - trifluoromethyl; acetylene; 1,3-dipolar reaction; intramolecular Wittig reaction; trifluoroacetylphosphonium ylide; pyrazole; diazomethane; phenyl azide