96256-54-1

Upstream product

• 186581-53-3 diazomethane 
• 60676-51-9 methyl (Z)-2-(acetylamino)-3-phenylpropenoate 
• 21462-02-2 methyl (Z)-2-benzoylamino-3-phenyl-2-propenoate 
• 13257-30-2 (E)-N-benzoyldidehydrophenylalanine methyl ester 
• 637-44-5 phenylpropyolic acid 
• 5932-28-5 4-phenyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 4891-38-7 phenylpropynoic acid methyl ester 
• 256658-45-4 C₅H₁₄N₂OSi 
• 400877-57-8 1-methyl-4-nitro-1H-pyrazole-3-carboxylic acid methyl ester 
• 4598-86-1 1-methyl-4-nitro-1H-pyrazole-3-carboxylic acid 
• 637336-53-9 4-amino-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 211738-66-8 4-bromo-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 98-80-6 phenylboronic acid 

Relevant academic research and scientific papers

SUBSTITUTED 2-AZABICYCLO[3.1.1]HEPTANE AND 2-AZABICYCLO[3.2.1]OCTANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

There is provided a compound of formula (I), wherein L1 to L3, R1 to R4, X, A and B have meanings given in the description, and pharmaceutically acceptable salts, solvates and prodrugs thereof, which compounds are useful as antagonists of the orexin-1 and orexin-2 receptors or as selective antagonists of the orexin-1 receptor, and thus, in particular, in the treatment or prevention of inter alia substance dependence, addiction, anxiety disorders, panic disorders, binge eating, compulsive disorders, impulse control disorders, cognitive impairment and Alzheimer's disease.

2-AZABICYCLO[3.1.1] DERIVATIVES AS ANTAGONISTS OF THE OREXIN-1 AND OREXIN-2 RECEPTORS

There is provided a compound of formula I, wherein L1, R1, R2, R5, X, A and B have meanings given in the description, and pharmaceutically acceptable salts, solvates and prodrugs thereof, which compounds are useful as antagonists of the orexin-1 and orexin-2 receptors or as selective antagonists of the orexin-1 receptor, and thus, in particular, in the treatment or prevention of inter alia substance dependence, addiction, anxiety disorders, panic disorders, binge eating, compulsive disorders, impulse control disorders, cognitive impairment and Alzheimer's disease.

Novel generation of azomethine imines from α-silylnitrosamines by 1,4- silatropic shift and their cycloaddition

Novel and facile generation of azomethine imines from α- silylnitrosamines and subsequent cycloaddition with dipolarophiles leading to a variety of pyrazole derivatives have been developed. The key to the reaction is a 1,4-silatropic shift caused by stron

Action of Diazomethane on Methyl (Z(or E))-2-(Acylamino)cinnamates. A New Route to Methyl (Z)-2-(Acylamino)-3-methylcinnamates

Diazomethane reacts with methyl (Z(or E))-2-acetamido(or benzamido)cinnamates (1,2) to afford regio- and stereospecifically (Z(or E))-4-phenyl-3-acetamido(or benzamido)-3-carbomethoxy-Δ1-pyrazolines (3,4). 3Z and 4Z undergo pyrolysis to afford

Studies on Organic Fluorine Compounds. XLII. Synthesis and Reactions of Phenyltrifluoromethylacetylenes

Phenyltrifluoromethylacetylene (4a) was synthesized by the pyrolysis of triphenylphosphonium α-(trifluoroacetyl)benzylide (3a), which was easily derived from benzyl halide (1a).This method can be used for the synthesis of 4-substituted-phenyltrifluoromethylacetylenes (4).The 1,3-dipolar reaction of 4 with diazomethane and phenyl azide proceeds readily to give trifluoromethylated pyrazoles and triazoles.Keywords - trifluoromethyl; acetylene; 1,3-dipolar reaction; intramolecular Wittig reaction; trifluoroacetylphosphonium ylide; pyrazole; diazomethane; phenyl azide