96291-79-1Relevant academic research and scientific papers
Preparation of Optically Active, Functionalized cis-Δ6-1-Octalones
Boger, Dale L.,Mullican, Michael D.,Hellberg, Mark R.,Patel, Mona
, p. 1904 - 1911 (2007/10/02)
A preparation of optically pure, functionalized cis-Δ6-octalones starting with (-)-β-pinene (92percent ee) is detailed.The conversion of (-)-β-pinene to (-)-cis-nopinol (>97percent ee) and its utilization in the preparation of (4R,9R,10R)-(+)-4-(acetylamino)-9-(methoxycarbonyl)-cis-Δ6-1-octalone ethylene ketal (1), a cis-Δ6-1-octalone possessing the correct absolute configuration at three appropriately functionalized chiral centers characteristic of the morphine-related analgesics, is described.
