96303-85-4Relevant academic research and scientific papers
Highly Selective Fluorescent Probe Based on 2-(2′-Dansylamidophenyl)-Thiazole for Sequential Sensing of Copper(II) and Iodide Ions
Kim, Bo-Yeon,Pandith, Anup,Cho, Chan Sik,Kim, Hong-Seok
, p. 163 - 168 (2019/01/16)
A novel highly selective fluorescent probe based on 2-(2′-dansylamidophenyl)-4-phenylthiazole (1) is developed for sequential sensing of copper(II) and iodide ions in acetonitrile. The fluorescence mechanism is based on cation-induced inhibition of excited-state intramolecular hydrogen transfer, intramolecular charge transfer, and metal–ligand electron/charge transfer. Subsequent iodide-induced extrusion of copper(II) results in partial revival of fluorescence. Probe 1 and its ensemble with copper (II) show high selectivity for copper(II) and iodide ions, respectively, in acetonitrile solution.
AMIDE DERIVATIVES AS SIRTUIN MODULATORS
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Page/Page column 73-74, (2009/06/27)
Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.
EXTRUSION REACTIONS-VI. TRANSFORMATIONS OF BETA(4-QUINAZOLINYLTHIO)KETONES TO 3-(BETA KETOALKYL)-4(3H)-QUINAZOLONE DERIVATIVES
Singh, Harjit,Deep, Kanwal
, p. 4937 - 4940 (2007/10/02)
4-(4-Quinazolinylthio)-butan-2-one and 3-(4-quinazolinylthio) propiophenone (4, R=CH3, C6H5) with POCl3 give 3-(3-oxobutyl)-4(3H)-quinazolone and 3-(2-benzoylethyl)-4(3H)-quinazolone (7, R=CH3, C6H5, X=O) via S N rearrangement followed by =C=S to =C=O conversion.Non-protic heterocyclic thioamides undergo similar oxidation.
