96315-84-3Relevant academic research and scientific papers
Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides
Bruno, Elvira,Buemi, Maria Rosa,Di Fiore, Anna,De Luca, Laura,Ferro, Stefania,Angeli, Andrea,Cirilli, Roberto,Sadutto, Daniele,Alterio, Vincenzo,Monti, Simona Maria,Supuran, Claudiu T.,De Simone, Giuseppina,Gitto, Rosaria
, p. 4316 - 4326 (2017/06/05)
On the basis of X-ray crystallographic studies of the complex of hCA II with 4-(3,4-dihydro-1H-isoquinoline-2-carbonyl)benzenesulfonamide (3) (PDB code 4Z1J), a novel series of 4-(1-aryl-3,4-dihydro-1H-isoquinolin-2-carbonyl)benzenesulfonamides (23-33) wa
Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides
Gitto, Rosaria,Ferro, Stefania,Agnello, Stefano,De Luca, Laura,De Sarro, Giovanbattista,Russo, Emilio,Vullo, Daniela,Supuran, Claudiu T.,Chimirri, Alba
experimental part, p. 3659 - 3664 (2009/09/27)
In previous studies we identified several 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives displaying potent anticonvulsant effects in different animal models of epilepsy. With the aim to deepen the structure-activity relationships (SAR) fo
1-Aryl-tetrahydroisoquinoline analogs as active anti-HIV agents in vitro
Cheng, Pi,Huang, Ning,Jiang, Zhi-Yong,Zhang, Quan,Zheng, Yong-Tang,Chen, Ji-Jun,Zhang, Xue-Mei,Ma, Yun-Bao
, p. 2475 - 2478 (2008/09/20)
A series of 1-aryl-6,7-dihydroxyl(methoxy)-1,2,3,4-tetrahydroisoquinolines (compounds 1-36) were synthesized via Pictet-Spengler cyclization. All the synthesized compounds were assayed for activities against HIV-1IIIB in C8166 cell cultures by
Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives
Gitto, Rosaria,Caruso, Roberta,Orlando, Valerie,Quartarone, Silvana,Barreca, Maria Letizia,Ferreri, Guido,Russo, Emilio,De Sarro, Giovambattista,Chimirri, Alba
, p. 7 - 12 (2007/10/03)
As a follow up of our previous structure-activity relationship and molecular modeling studies, we synthesized a novel series of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as potential non-competitive AMPA receptor antagonists. When te
Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist
Gitto, Rosaria,Barreca, Maria Letizia,De Luca, Laura,De Sarro, Giovambattista,Ferreri, Guido,Quartarone, Silvana,Russo, Emilio,Constanti, Andrew,Chimirri, Alba
, p. 197 - 200 (2007/10/03)
N-Acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives were designed and synthesized as potential noncompetitive AMPA receptor antagonists on the basis of molecular modeling studies. Sound-induced seizure testing showed that this class o
