96315-85-4Relevant academic research and scientific papers
Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides
Gitto, Rosaria,Ferro, Stefania,Agnello, Stefano,De Luca, Laura,De Sarro, Giovanbattista,Russo, Emilio,Vullo, Daniela,Supuran, Claudiu T.,Chimirri, Alba
experimental part, p. 3659 - 3664 (2009/09/27)
In previous studies we identified several 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives displaying potent anticonvulsant effects in different animal models of epilepsy. With the aim to deepen the structure-activity relationships (SAR) fo
Synthesis of stable azomethine ylides by the rearrangement of 1,3-dipolar cycloadducts of 3,4-dihydroisoquinoline-2-oxides with DMAD
Co?kun, Necdet,Tun?man, Selen
, p. 1345 - 1350 (2007/10/03)
1-Aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines were prepared according to a one-pot procedure involving the reaction of 2-(3,4- dimethoxyphenyl)-ethylamine with aromatic aldehydes in TFA at reflux. The tetrahydroisoquinolines were treated with Hsub
Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives
Gitto, Rosaria,Caruso, Roberta,Orlando, Valerie,Quartarone, Silvana,Barreca, Maria Letizia,Ferreri, Guido,Russo, Emilio,De Sarro, Giovambattista,Chimirri, Alba
, p. 7 - 12 (2007/10/03)
As a follow up of our previous structure-activity relationship and molecular modeling studies, we synthesized a novel series of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as potential non-competitive AMPA receptor antagonists. When te
