96326-44-2Relevant articles and documents
Development of the route of manufacture of an oral H1-H 3 antagonist
Harling, Sandra J.,Herbal, Karim,Langlade, Nathalie,Sanganee, Mahesh,Strachan, John B.,Turner, Peter G.,Whiting, Matthew P.,Bret, Guillaume,Loft, Mike,Negus, Alan,Shanahan, Steve
experimental part, p. 112 - 122 (2011/10/13)
A new route to an H1-H3 antagonist was developed to address scalability and environmental and cost of goods issues associated with the initial route.
Chemoselective hydrogenation of imides catalyzed by Cp*Ru(PN) complexes and its application to the asymmetric synthesis of paroxetine
Ito, Masato,Sakaguchi, Ayaka,Kobayashi, Chika,Ikariya, Takao
, p. 290 - 291 (2008/04/18)
This work represents the first catalytic hydrogenation of imides into amides and primary alcohols, in which the unique chemoselectivity is originated from the bifunctional nature of ruthenium-NH moiety in the catalyst. Copyright
Asymmetric synthesis catalyzed by chiral ferrocenylphosphine transition metal complexes. 10 gold(I)-catalyzed asymmetric aldol reaction of isocyanoacetate
Hayashi, Tamio,Sawamura, Masaya,Ito, Yoshihiko
, p. 1999 - 2012 (2007/10/02)
Optically active ferrocenylbisphosphine ligands containing 2-(dialkylamino)ethylamino group on the ferrocenylmethyl position have been prepared and used for the gold(I)-catalyzed asymmetric aldol reaction of isocyanoacetate with aldehydes. Six-membered ring amines, such as morpholino or piperidino group, at the terminal of the side chain were most stereoselective to give optically active trans-4- methoxycarbonyl-5-alkyl-2-oxazolines (up to 97% ee) with high enantio- and diastereoselectivity in a quantitative yield.
